Searching for human oncoviruses: Histories, challenges, and opportunities
Searching for human oncoviruses: Histories, challenges, and opportunities
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DOI：
10.1002/jcb.26717
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发表时间：
2018-06-01
影响因子：
4
通讯作者：
Li, Dawei
中科院分区：
文献类型：
--
作者：
Cao, Jian;Li, Dawei
肿瘤病毒对癌症负担有显著贡献。经过世纪的肿瘤病毒学研究，发现了七种公认的人类肿瘤病毒，累积起来约占人类癌症病例的15%。病毒引起的癌症在很大程度上可以通过接种疫苗来预防。识别更多的肿瘤病毒和病毒引起的肿瘤将促进癌症预防和精准医学，使受影响的个人和整个社会受益。发现人类肿瘤病毒的历史性成功为指导后测序时代的新研究工作提供了独特的教训。将这些先驱研究的经验与新兴的高通量技术相结合，必将加速新的发现，并提高我们对剩余人类肿瘤病毒的认识。
Oncoviruses contribute significantly to cancer burden. A century of tumor virological studies have led to the discovery of seven well-accepted human oncoviruses, cumulatively responsible for approximately 15% of human cancer cases. Virus-caused cancers are largely preventable through vaccination. Identifying additional oncoviruses and virus-caused tumors will advance cancer prevention and precision medicine, benefiting affected individuals, and society as a whole. The historic success of finding human oncoviruses has provided a unique lesson for directing new research efforts in the post-sequencing era. Combing the experiences from these pioneer studies with emerging high-throughput techniques will certainly accelerate new discovery and advance our knowledge of the remaining human oncoviruses.