Prefrontal cortex is necessary for long-term social recognition memory in mice
Prefrontal cortex is necessary for long-term social recognition memory in mice
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DOI：
10.1016/j.bbr.2022.114051
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发表时间：
2022-08
影响因子：
2.7
通讯作者：
T. Sakamoto;Joi Yashima
中科院分区：
文献类型：
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作者：
T. Sakamoto;Joi Yashima
前额叶皮层（PFC）在人类和啮齿动物的社会认知和情绪调节中起着关键作用;然而，其在小鼠的社会识别记忆中的参与尚不清楚。在此，我们研究了PFC在C57 BL/6 J雄性小鼠短期和长期社会认知记忆、社会动机和焦虑相关行为中的作用。假手术对照组和PFC损伤组小鼠进行了四种不同的行为测试。在由连续3天的3次每日试验组成的社会识别测试中，对照小鼠在每天内和跨天研究幼年刺激小鼠所花费的时间较少。相比之下，虽然PFC损伤小鼠的社会调查行为在三次试验中每天都有所下降，但在3天的测试期内并没有下降。这些结果表明，前额叶皮层在长期而非短期的社会识别记忆中具有重要作用。对照组和PFC损伤组小鼠在三室实验中表现出相似的社会动机--两组小鼠都喜欢幼年小鼠而不喜欢成年小鼠。此外，PFC病变对焦虑相关行为或一般活动在明-暗转换测试或开放领域的测试没有影响。我们的研究结果表明，PFC是必不可少的长期社会识别记忆，它在高阶社会认知中起着关键作用。
The prefrontal cortex (PFC) plays critical roles in social cognition and emotional regulation in humans and rodents; however, its involvement in social recognition memory in mice remains unclear. Here, we examined the roles of the PFC in short-term and long-term social recognition memory, social motivation, and anxiety-related behavior in C57BL/6J male mice. Sham control and PFC-lesioned mice underwent four different behavioral tests. In the social recognition test, composed of three daily trials over 3 consecutive days, the control mice spent less time investigating the juvenile stimulus mouse both within each day and across days. By contrast, while social investigation behavior in PFC-lesioned mice decreased across the three trials within each day, it did not decrease over the 3-day testing period. These results indicate that the PFC has an important role in long-term, but not short-term, social recognition memory. The control and PFC-lesioned mice exhibited similar social motivation in the three-chamber test – both groups preferred the juvenile mouse to the empty cylinder and did not prefer the adult mouse. In addition, the PFC lesion had no impact on anxiety-related behavior or general activity in the light–dark transition test or the open field test. Our findings demonstrate that the PFC is essential for long-term social recognition memory and that it plays a critical role in higher-order social cognition.