Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.
Endothelial cell junctions and the regulation of vascular permeability and leukocyte transmigration.
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DOI：
10.1111/j.1538-7836.2008.03087.x
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发表时间：
2008-09
期刊：
影响因子：
--
通讯作者：
Burridge K
中科院分区：
文献类型：
--
作者：
Aghajanian A;Wittchen ES;Allingham MJ;Garrett TA;Burridge K
血管系统的内皮衬里形成血液和下层组织之间的物理屏障。相邻内皮细胞之间的连接被动态调节，以维持血管内稳态并支持炎症期间白细胞的跨内皮迁移。多种因素启动细胞内信号传导途径，调节连接复合物的打开和重新密封。本文综述了血管活性因子和白细胞粘附结合在内皮细胞内启动的三种主要信号通路：Rho GTPases，活性氧和连接蛋白的酪氨酸磷酸化。这些途径通过影响连接蛋白的稳定性或调节它们的相互作用来调节连接通透性。虽然在理解这些途径的关系方面取得了很大进展，但仍有许多问题有待回答。对影响内皮连接的信号级联的充分理解应该为涉及过度渗透性或不适当的白细胞浸润到组织中的疾病确定新的治疗靶点。
The endothelial lining of the vasculature forms the physical barrier between the blood and underlying tissues. Junctions between adjacent endothelial cells are dynamically modulated to sustain vascular homeostasis and to support the transendothelial migration of leukocytes during inflammation. A variety of factors initiate intracellular signaling pathways which regulate the opening and resealing of junctional complexes. This review focuses on three primary signaling pathways initiated within endothelial cells by the binding of vasoactive factors and leukocyte adhesion: Rho GTPases, reactive oxygen species, and tyrosine phosphorylation of junctional proteins. These pathways converge to regulate junctional permeability, either by affecting the stability of junctional proteins or by modulating their interactions. Although much progress has been made in understanding the relationships of these pathways, many questions remain to be answered. A full understanding of the signaling cascades that affect endothelial junctions should identify novel therapeutic targets for diseases that involve excessive permeability or inappropriate leukocyte infiltration into tissues.
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DOI：
10.1083/jcb.200112126
发表时间：
2002-06-24
期刊：
The Journal of cell biology
影响因子：
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作者：
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