The effect of calcitonin on the prechordal mesoderm, neural plate and neural crest of Xenopus embryos
The effect of calcitonin on the prechordal mesoderm, neural plate and neural crest of Xenopus embryos
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降钙素对非洲爪蟾胚胎脊索前中胚层、神经板和神经嵴的影响
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发表时间：
1985
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影响因子：
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通讯作者：
Burgess Am
中科院分区：
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作者：
Burgess Am
在原肠胚形成期间，在环境水中用22微克/升的鲑鱼降钙素处理的发育中的爪蟾胚胎发育成幼虫，表现出眼间距离的减小。鉴于降钙素的低血钙特性和钙离子在细胞聚集中的重要性，这种现象已被归因于细胞粘附的改变，其导致原肠胚形成期间细胞迁移错误，从而导致原肠顶和上覆神经板的索前区异常。受影响的标本的组织学检查表明，从脊索前中胚层和脊索前板产生的主要缺陷是无舌和严重减少的口腔。这导致头部变窄，从而导致两眼间距离减小。伴随着这种效应的是间脑和第三脑室的变形，这可能表明扰动的下颏前区对神经板的错误诱导。
: Developing Xenopus embryos treated during gastrulation with 22 micrograms/l of salmar calcitonin in the ambient water develop into larvae exhibiting a decrease in interocular distance. In view of the hypocalcaemic properties of calcitonin and the importance of calcium ions in cell aggregation, this phenomenon has been attributed to an alteration in cell adhesion which results in faulty cell migration during gastrulation with consequent abnormalities of the prechordal region of the archenteron roof and the overlying neural plate. Histological examination of affected specimens shows that the principal defect arising from the prechordal mesoderm and prechordal plate is aglossia and a severely reduced oral cavity. This results in narrowing of the head and consequent decrease in interocular distance. Accompanying this effect is distortion of the diencephalon and third ventricle, which may indicate faulty induction of the neural plate by the perturbed subjacent prechordal region.