Peripheral anti-inflammatory actions of corticotropin-releasing factor.
Peripheral anti-inflammatory actions of corticotropin-releasing factor.
复制标题
促肾上腺皮质激素释放因子的外周抗炎作用。
DOI：
10.1002/9780470514368.ch13
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Thomas,HA
中科院分区：
文献类型：
--
作者：
Wei,ET;Gao,GC;Thomas,HA
肿胀、水肿、以及来自血管室的液体和蛋白质的损失是在严重损伤后在活组织中观察到的立即反应。促肾上腺皮质激素释放因子（CRF）超家族的肽具有防止组织损伤后发生血管渗漏的不寻常特性。例如，CRF降低了暴露于高温或极冷后麻醉大鼠爪子中的蛋白质外渗、水肿和肿胀，暴露于甲醛后气管粘膜中的蛋白质外渗、水肿和肿胀，刀切后骨骼肌中的蛋白质外渗、水肿和肿胀，以及冷冻后大脑皮层中的蛋白质外渗、水肿和肿胀。CRF的抗炎作用与类固醇释放或肿胀作用无关。CRF是炎症介质（如组胺和P物质）的功能性拮抗剂。它抑制神经源性炎症，但与无髓鞘感觉神经元的相互作用不能解释CRF的广泛抗炎活性。局部应用CRF可以防止组胺诱导的仓鼠眼袋渗漏，并且在血管和血管渗漏部位附近的上皮细胞上发现了碘化CRF的可替换结合位点。这些结果表明外周部位的行动。CRF可能是第一个被证明在体内具有强效抗炎激动剂作用的肽类激素的例子。
Swelling, oedema, and loss of fluids and protein from the vascular compartment are immediate responses seen in living tissues after severe injury. Peptides of the corticotropin‐releasing factor (CRF) superfamily have the unusual property of preventing the vascular leakage that occurs in tissues after damage. For example, CRF decreased protein extravasation, oedema and swelling in the anaesthetized rat's paw after exposure to heat or to extreme cold, in tracheal mucosa after exposure to formaldehyde, in skeletal muscle after a knife cut, and in brain cortex after freezing. The anti‐inflammatory actions of CRF were independent of steroid release or hypotensive effects. CRF was a functional antagonist of inflammatory mediators such as histamine and substance P. It inhibited neurogenic inflammation, but interactions with unmyelinated sensory neurons did not account for the wide range of CRF's anti‐inflammatory activities. Localized application of CRF prevented histamine‐induced leaks in the hamster cheek pouch, and displaceable binding sites to iodinated CRF were found on blood vessels and on epithelial cells in close proximity to sites of vascular leakage. These results indicated peripheral sites of action. CRF may be the first example of a peptide hormone demonstrated to have potent anti‐inflammatory agonist actionsin vivo.