Elevated blood pressure is associated with advanced brain aging in mid-life: A 30-year follow-up of The CARDIA Study.
Elevated blood pressure is associated with advanced brain aging in mid-life: A 30-year follow-up of The CARDIA Study.
复制标题
血压升高与中年大脑老化有关：CARDIA 研究的 30 年随访。
DOI：
10.1002/alz.12725
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Yaffe,Kristine
中科院分区：
文献类型：
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作者：
Dintica,ChristinaS;Habes,Mohamad;Erus,Guray;Vittinghoff,Eric;Davatzikos,Christos;Nasrallah,IlyaM;Launer,LenoreJ;Sidney,Stephen;Yaffe,Kristine
BackgroundHigh blood pressure (BP) is a risk factor for late‐life brain health; however, the association of elevated BP with brain health in mid‐life is unclear.MethodsWe identified 661 participants from the Coronary Artery Risk Development in Young Adults Study (age 18–30 at baseline) with 30 years of follow‐up and brain magnetic resonance imaging at year 30. Cumulative exposure of BP was estimated by time‐weighted averages (TWA). Ideal cardiovascular health was defined as systolic BP < 120 mm Hg, diastolic BP < 80 mm Hg. Brain age was calculated using previously validated high dimensional machine learning pattern analyses.ResultsEvery 5 mmHg increment in TWA systolic BP was associated with approximately 1‐year greater brain age (95% confidence interval [CI]: 0.50–1.36) Participants with TWA systolic or diastolic BP over the recommended guidelines for ideal cardiovascular health, had on average 3‐year greater brain age (95% CI: 1.00–4.67; 95% CI: 1.45–5.13, respectively).ConclusionElevated BP from early to mid adulthood, even below clinical cut‐offs, is associated with advanced brain aging in mid‐life.
