Inflammation and cancer: Breast cancer as a prototype
Inflammation and cancer: Breast cancer as a prototype
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DOI：
10.1016/j.breast.2007.07.013
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发表时间：
2007-12-01
期刊：
影响因子：
3.9
通讯作者：
Allavena, Paola
中科院分区：
文献类型：
--
作者：
Mantovani, Alberto;Marchesi, Federica;Allavena, Paola
肿瘤相关巨噬细胞（TAM）是许多肿瘤间质的主要炎症成分，能够影响肿瘤组织的不同方面。许多观察表明，TAM表达几种M2相关的促肿瘤功能，包括促进血管生成、基质重塑和抑制适应性免疫。TAM在癌症中的促肿瘤作用得到了临床研究的进一步支持，这些研究发现肿瘤的高巨噬细胞含量与患者预后不良之间存在相关性，并且有证据表明长期使用非甾体抗炎药可以降低几种癌症的风险。在这里，我们讨论的证据支持的观点，TAM代表了一个独特的和不同的M2偏髓人群和抗癌治疗的潜在目标。(C)2007爱思唯尔有限公司保留所有权利。
Tumor-associated macrophages (TAM) represent the major inflammatory component of the stroma of many tumors, able to affect different aspects of the neoplastic tissue. Many observations indicate that TAM express several M2-associated protumoral functions, including promotion of angiogenesis, matrix remodeling and suppression of adaptive immunity. The protumoral role of TAM in cancer is further supported by clinical studies that found a correlation between the high macrophage content of tumors and poor patient prognosis and by evidence showing that long-term use of non-steroidal anti-inflammatory drugs reduces the risk of several cancers. Here, we discuss evidence supporting the view that TAM represent a unique and distinct M2-skewed myeloid population and a potential target of anti-cancer therapy. (C) 2007 Elsevier Ltd. All rights reserved.