Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
Rheumatoid nodulosis during methotrexate therapy in a patient with rheumatoid arthritis.
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DOI：
10.1007/s10165-006-0522-2
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发表时间：
2006-01-01
影响因子：
2.2
通讯作者：
Kimura, Tomoastu
中科院分区：
文献类型：
--
作者：
Matsushita, Isao;Uzuki, Miwa;Kimura, Tomoastu
我们报告一位62岁男性类风湿性关节炎（RA）谁开发结节后甲氨蝶呤（MTX）治疗。结节上皮样细胞表达基质金属蛋白酶（MMP）-2、MMP-3、MMP-9和Ki 67。从同一患者获得的滑膜组织对MMP-3、MMP-9和Ki 67呈阴性。这项研究表明，MTX诱导的结节在MMP表达方面与滑膜组织不同，表明存在不同的病理机制和差异MTX敏感性。
We report a 62-year-old man with rheumatoid arthritis (RA) who developed nodulosis after methotrexate (MTX) treatment. The epithelioid cells of nodules were positive for matrix metalloproteinases (MMP)-2, MMP-3, MMP-9, and Ki67. The synovial tissues obtained from the same patient were negative for MMP-3, MMP-9, and Ki67. This study demonstrated that MTX-induced nodules are different from synovial tissues in terms of MMP expression, suggesting the presence of different pathologic mechanisms and differential MTX susceptibility.