ADP-ribose transfer reactions : mechanisms and biological significance

ADP-ribose transfer reactions : mechanisms and biological significance
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ADP-核糖转移反应：机制和生物学意义

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发表时间：
1989
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通讯作者：
E. Jacobson
E. Jacobson
中科院分区：
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文献类型：
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作者：
M. Jacobson;E. Jacobson

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NAD（烟酰胺腺嘌呤二核苷酸）在生物系统中的作用目前的兴趣集中在ADP-核糖转移反应。这些似乎从根本上参与了许多生理过程的调节。因此，本专著的贡献代表了烟酸代谢非常活跃的研究范围。所涉及的主要议题是：- ADP-核糖基化的酶学-ADP-核糖基化和染色质功能-致癌和分化- NAD代谢和化疗-ADP-核糖基化和信号转导-ADP-核糖基化的分子遗传学方法
Current interest in NAD (Nicotinamide adenine dinucleotide) in biological systems focuses on its role in ADP-ribose transfer reactions. These appear to be fundamentally involved in the regulation of many physiological processes. The contributions in this monograph thus represent the range of research in the very active investigation of niacin metabolism. The major topics covered are: - Enzymology of ADP-Ribosylation - ADP-Ribosylation and Chromatin Function - Carcinogenesis and Differentiation - NAD Metabolism and Chemotherapy - ADP-Ribosylation and Signal Transduction - Molecular Genetic Approaches to ADP-Ribosylation