Total synthesis of the teicoplanin aglycon
Total synthesis of the teicoplanin aglycon
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DOI：
10.1021/ja001663j
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发表时间：
2000-08-02
影响因子：
15
通讯作者：
McAtee, JJ
中科院分区：
文献类型：
--
作者：
Boger, DL;Kim, SH;McAtee, JJ
Teicoplanin1, 2 is a complex of five antibiotics isolated from Actinoplanes teichomyceticus that are related to vancomycin3-8 which is enlisted as the drug of last resort for treatment of resistant bacterial infections or for patients allergic to β-lactam antibiotics. 6 It is 2-8-fold more potent, possesses a lower toxicity, exhibits a longer half-life in man (40 vs 6 h), and is easier to administer and monitor than vancomycin.
