Fat Mass Exerts a Greater Effect on Cortical Bone Mass in Girls than Boys
Fat Mass Exerts a Greater Effect on Cortical Bone Mass in Girls than Boys
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DOI：
10.1210/jc.2009-1907
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发表时间：
2010-02-01
影响因子：
5.8
通讯作者：
Tobias, Jonathan H.
中科院分区：
文献类型：
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作者：
Sayers, Adrian;Tobias, Jonathan H.
背景：脂肪质量(FM)和瘦质量(LM)对男孩和女孩皮质骨发育的影响方式是否不同尚不清楚。目的：研究全身脂肪质量和瘦质量对皮质骨质量和几何参数的影响。设计/地点：我们进行了一项纵向出生队列研究，雅芳亲子纵向研究。参与者：共有4005名男孩和女孩(平均年龄15.5岁)参与研究。结果：我们测量了皮质骨质量、皮质骨矿含量(BMCC)、皮质骨密度、骨膜周长(PC)。结果：男性和女孩Lm与BMCC呈相似的正相关[回归系数95%可信区间(CI)；性别互动：男孩/女孩，0.952(0.908，0.997)；P=0.85.然而，LM影响骨量的机制因性别不同而不同，因为在女孩中，Lm与PC的正相关更强[男孩，0.579(0.522，0.635)；女孩，0.799(0.722，0.875)；P<；0.0001]，但只与男孩的皮质骨密度相关[男孩，0.443(0.382，0.505)；女孩，0.014(-0.070，0.097)；P<；0.0001]。在女孩中，FM与骨髓基质细胞癌有更强的正相关[男孩，0.227(0.185，0.269)；女孩，0.355(0.319，0.392)；P<；0.0001]。这既反映了女孩FM与PC的更大的正相关[男孩，0.213(0.174，0.253)；女孩，0.312(0.278，0.347)；P=0.0002]，也反映了Fm与骨内周长的更强的负相关[男孩，-0.059(-0.096，0.021)；女孩，-0.181(-0.215，-0.146)；P<；0.0001]结论：在男孩和女孩中，FM刺激皮质骨量增加的程度相似，而FM对女孩皮质骨量增加的刺激作用更强，反映了女性FM刺激骨膜生长和抑制骨内膜扩张的更大倾向。(临床内分泌代谢酶95：699-706,2010)
Context: It is unclear whether fat mass (FM) and lean mass (LM) differ in the way they influence cortical bone development in boys and girls.Objective: The aim of the study was to investigate the contributions of total body FM and LM to parameters related to cortical bone mass and geometry.Design/Setting: We conducted a longitudinal birth cohort study, the Avon Longitudinal Study of Parents and Children.Participants: A total of 4005 boys and girls (mean age, 15.5 yr) participated in the study.Outcome Measures: We measured cortical bone mass, cortical bone mineral content (BMCC), cortical bone mineral density, periosteal circumference (PC), and endosteal circumference by tibial peripheral quantitative computed tomography.Results: LM had a similar positive association with BMCC in boys and girls [regression coefficients with 95% confidence interval (CI); P for gender interactions: boys/girls, 0.952 (0.908, 0.997); P = 0.85]. However, the mechanisms by which LM influenced bone mass differed according to gender because LM was positively associated with PC more strongly in girls [boys, 0.579 (0.522, 0.635); girls, 0.799 (0.722, 0.875); P < 0.0001], but was only associated with cortical bone mineral density in boys [boys, 0.443 (0.382, 0.505); girls, 0.014 (-0.070, 0.097); P < 0.0001]. There was a stronger positive association between FM and BMCC in girls [boys, 0.227 (0.185, 0.269); girls, 0.355 (0.319, 0.392); P < 0.0001]. This reflected both a greater positive association of FM with PC in girls [boys, 0.213 (0.174, 0.253); girls, 0.312 (0.278, 0.347); P = 0.0002], and a stronger negative association with endosteal circumference(PC) [boys, -0.059 (-0.096, 0.021); girls, -0.181 (-0.215, -0.146); P < 0.0001].Conclusions: Whereas LM stimulates the accrual of cortical bone mass to a similar extent in boys and girls, FM is a stronger stimulus for accrual of cortical bone mass in girls, reflecting a greater tendency in females for FM to stimulate periosteal growth and suppress endosteal expansion. (J Clin Endocrinol Metab 95: 699-706, 2010)