Effect of hypoxic exercise on atrial natriuretic factor and aldosterone regulation.
Effect of hypoxic exercise on atrial natriuretic factor and aldosterone regulation.
复制标题
低氧运动对心房钠尿因子和醛固酮调节的影响。
DOI：
10.1093/ajh/4.4.341
复制
发表时间：
1991
影响因子：
3.2
通讯作者：
Shenker,Y
中科院分区：
文献类型：
--
作者：
Lawrence,DL;Shenker,Y
为评价心钠素（ANF）在低氧运动时醛固酮分泌与肾素-血管紧张素系统分离中可能的生理作用，对12名年龄在18 ~ 24岁的未接受训练的男性进行了为期30分钟的低氧（16%O2）和常氧（室内空气）自行车运动试验。调整工作负荷，使个体心率保持在先前测量的最大值的70%至75%范围内。血红蛋白饱和度在缺氧期间从98 ± 0.1%下降到90 ± 0.4%（P <0.01）。血浆醛固酮水平在两种呼吸条件下均显著升高（P <0.01），但在低氧条件下比常氧条件下平均低36%（P <0.001）。在两种条件下，血浆心钠素水平在运动过程中均升高（P <0.01），但在低氧时比常氧时高45%（P <0.001）。血浆肾素活性、促肾上腺皮质激素、皮质醇、钾和收缩压在两个研究日的运动过程中均升高（与基础水平相比，P <0.01），但在常氧和低氧条件下无差异。血浆pH值在低氧运动期间略高（P <0.05，与常氧相比）。我们的结论是，急性低氧血症是一个有力的增强刺激ANF释放动态运动过程中，ANF可能是在这些条件下，从肾素-血管紧张素系统的醛固酮分泌的解离的一个促成因素。美国高血压杂志1991;4：341-347
To evaluate the possible physiologic role of atrial natriuretic factor (ANF) in the observed dissociation of aldosterone secretion from the renin - angiotensin system during hypoxic exercise, 12 untrained men, ages 18 to 24, were studied on two separate days for 30 m i n during hypoxic (16% 02) a n d normoxic (room air) exercise on a bicycle ergometer. Workloads were adjusted to produce individual heart rates that remained within 70 to 75% of their previously measured maximum. Hemoglobin saturation decreased during hypoxia from 98 ± 0.1% to 90 ± 0.4% (P < .01). Plasma aldosterone levels increased significantly (P < .01) under both breathing conditions, yet were on average 36% lower during hypoxia than during normoxia (P < .001). Plasma ANF levels increased during exercise under both conditions (P < .01), yet levels were 45% greater during hypoxia than during normoxia (P < .001). Plasma renin activity, adrenocorticotropic hormone, Cortisol, potassium, and systolic blood pressure increased during exercise on both study days (P < .01, compared to basal level), and showed no difference between normoxic and hypoxic conditions. Plasma pH was slightly higher during hypoxic exercise (P < .05, compared to normoxia). We conclude that acute hypoxemia is a potent enhancing stimulus for ANF release during dynamic exercise and that ANF is probably a contributing factor in the dissociation of aldosterone secretion from the renin - angiotensin system under these conditions. Am J Hypertens 1991;4:341–347