Medical devices on chips
Medical devices on chips
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DOI：
10.1038/s41551-017-0045
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发表时间：
2017-03-01
影响因子：
28.1
通讯作者：
Phillips, K. Scott
中科院分区：
文献类型：
--
作者：
Guan, Allan;Hamilton, Parisa;Phillips, K. Scott
医疗器械技术的发展受到动物试验和临床试验的财务和伦理考虑的限制。正在开发器官芯片系统以加速药物开发，但在医疗设备的开发和测试中使用该技术几乎没有得到认可或支持。在本视角中，我们介绍了片上医疗设备 (MDoC) 的概念，重点介绍了可能的应用，并讨论了微流控高通量技术与传统测试相比显着节省时间和成本的潜力。 MDoC 不是测试整个宏观设备，而是能够概括与医疗设备使用相关的生理组中的生物功能，并测试与设备组件的交互。在诊所中，MDoC 还可以纳入个体人体样本进行个性化诊断。我们还回顾了芯片器官技术关键要素与医疗设备测试集成的研究。
The development of medical-device technology is constrained by the financial and ethical considerations of animal testing and clinical trials. Organ-on-a-chip systems are being developed to speed up drug development, yet there has been little recognition or support for the use of this technology in the development and testing of medical devices. In this Perspective, we introduce the concept of medical-device-on-a-chip (MDoC), highlight possible applications and discuss the potential of microfluidic high-throughput technologies for achieving significant time and cost savings over conventional testing. Rather than testing an entire macroscale device, a MDoC has the ability to recapitulate biological function in a physiome associated with medical-device use and to test interactions with device components. In the clinic, MDoCs could also incorporate individual human samples for personalized diagnostics. We also review research towards the integration of key elements of organ-on-a-chip technologies with medical-device testing.