Prognostic significance of molecular alterations in human pancreatic carcinoma - an immunohistological study
Prognostic significance of molecular alterations in human pancreatic carcinoma - an immunohistological study
复制标题
DOI：
10.1007/pl00008076
复制
发表时间：
1998-04-01
影响因子：
2.3
通讯作者：
Beger, HG
中科院分区：
文献类型：
--
作者：
Gansauge, F;Gansauge, S;Beger, HG
背景：在过去的十年中，许多分子改变已被描述为胰腺癌。然而，这些改变的临床和预后价值已被讨论，是有争议的。方法：对82例胰腺腺癌进行免疫组化研究。使用特异性抗体，评估EGF、EGF受体、cERB-B2、p53、p21（CIP 1）、细胞周期蛋白-D1、BCL-2、CD 95和KI 67的表达。结果：44-69%的胰腺癌中存在不同分子的过表达。在临床病理特征方面，p53阳性在晚期和未分化的恶性肿瘤中更常见（P
Background: During the last decade, many molecular alterations have been described for pancreatic carcinomas. However, the clinical and prognostic value of these alterations has been discussed and is controversial. Methods: An immunhistochemical study was performed in 82 cases of adenocarcinoma of the pancreas. Using specific antibodies, expression of EGF, EGF-receptor, cERB-B2, p53, p21(CIP1), cyclin-D1, BCL-2, CD95 and KI67 was evaluated. Results: Overexpression of the different molecules was found in 44-69% of the pancreatic carcinomas. With regard to clinico-pathological features, p53 positivity was more frequently found in advanced and undifferentiated rumours (P