Lack of an effect of vitamin E on lifespan of mice
Lack of an effect of vitamin E on lifespan of mice
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DOI：
10.1023/a:1011589218219
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发表时间：
2001-01-01
期刊：
影响因子：
4.5
通讯作者：
Trainer, KJ
中科院分区：
文献类型：
--
作者：
Morley, AA;Trainer, KJ
据推测，衰老是由于氧化自由基的作用对大分子，特别是DNA的损害的积累造成的。这种可能性预示着服用抗氧化剂可能会延长寿命，但以前关于这一预测的数据是相互矛盾的。三组小鼠从受孕到死亡，在整个生命周期中暴露于饮食中20、40和400 mg/kg的维生素E。没有观察到对寿命的影响，三组的中位寿命分别为804、830和801天。这项研究的设计也使父母年龄对雌性后代寿命的影响得以寻求，但没有检测到影响。
It has been speculated that ageing results from accumulation of damage to macromolecules, particularly DNA, owing to the action of oxidising free radicals. This possibility would predict that administration of anti-oxidants might prolong lifespan, but previous data on this prediction are conflicting. Three groups of mice were exposed throughout life, from the time of conception until death, to 20, 40 and 400 mg/kg of vitamin E in the diet. No effect on lifespan was observed and the median lifespans in the three groups were 804, 830 and 801 days, respectively. The design of the study also enabled an effect of parental age on lifespan of female progeny to be sought, but no effect was detected.