Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children.
Prenatal Residential Proximity to Agricultural Pesticide Use and IQ in 7-Year-Old Children.
复制标题
DOI：
10.1289/ehp504
复制
发表时间：
2017-05-25
影响因子：
10.4
通讯作者：
Eskenazi B
中科院分区：
文献类型：
--
作者：
Gunier RB;Bradman A;Harley KG;Kogut K;Eskenazi B
农业农药使用附近的住宅与神经管缺陷和自闭症有关，但更微妙的结果，如认知，尚未得到研究。我们评估了7岁儿童的产前居住环境与潜在神经毒性农药的农业使用之间的关系。参与者包括生活在加州萨利纳斯农业山谷的母亲和儿童，他们参加了萨利纳斯母亲和儿童健康评估中心（CHAMACOS）的研究。我们使用地理信息系统、居住地和加州综合农药使用报告数据，估算了怀孕期间孕产妇住所1公里范围内的农药使用情况。我们使用回归模型评估了产前居住环境与农业使用五种潜在神经毒性农药（有机磷、氨基甲酸酯、拟除虫菊酯、新烟碱和锰类杀菌剂）和五种有机磷（甲胺磷、毒死蜱、二嗪农、马拉硫磷和甲基氧甲氧磷）的接近程度和7岁儿童的认知能力。所有模型均包括产前尿磷酸二烷基代谢物浓度。我们观察到，有机磷农药毒性加权使用每增加一个标准差，全面智商（full IQ）下降2.2点[95%可信区间（CI）：，]，言语理解（Verbal Comprehension）下降2.9点（95% CI:,）。在不同的模型中，我们观察到两种有机磷（乙酰甲胺磷和氧去甲氧胺）和三种神经毒性农药（拟除虫菊酯、新烟碱类和锰类杀菌剂）的使用每增加一个标准差，全尺寸智商就会出现类似的下降。本研究确定了母亲居住地附近的农业使用神经毒性农药与儿童较差的神经发育之间的潜在关系。https://doi.org/10.1289/EHP504
Residential proximity to agricultural pesticide use has been associated with neural tube defects and autism, but more subtle outcomes such as cognition have not been studied. We evaluated the relationship between prenatal residential proximity to agricultural use of potentially neurotoxic pesticides and neurodevelopment in 7-year-old children. Participants included mothers and children () living in the agricultural Salinas Valley of California enrolled in the Center for the Health Assessment of Mothers and Children of Salinas (CHAMACOS) study. We estimated agricultural pesticide use within 1 km of maternal residences during pregnancy using a geographic information system, residential location, and California’s comprehensive agricultural Pesticide Use Report data. We used regression models to evaluate prenatal residential proximity to agricultural use of five potentially neurotoxic pesticide groups (organophosphates, carbamates, pyrethroids, neonicotinoids, and manganese fungicides) and five individual organophosphates (acephate, chlorpyrifos, diazinon, malathion, and oxydemeton-methyl) and cognition in 7-year-old children. All models included prenatal urinary dialkyl phosphate metabolite concentrations. We observed a decrease of 2.2 points [95% confidence interval (CI): , ] in Full-Scale IQ and 2.9 points (95% CI: , ) in Verbal Comprehension for each standard deviation increase in toxicity-weighted use of organophosphate pesticides. In separate models, we observed similar decrements in Full-Scale IQ with each standard deviation increase of use for two organophosphates (acephate and oxydemeton-methyl) and three neurotoxic pesticide groups (pyrethroids, neonicotinoids, and manganese fungicides). This study identified potential relationships between maternal residential proximity to agricultural use of neurotoxic pesticides and poorer neurodevelopment in children. https://doi.org/10.1289/EHP504