Mycophenolic acid-induced replication arrest, differentiation markers and cell death of androgen-independent prostate cancer cells DU145
Mycophenolic acid-induced replication arrest, differentiation markers and cell death of androgen-independent prostate cancer cells DU145
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DOI：
10.1016/j.canlet.2005.01.006
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发表时间：
2006-01-08
期刊：
影响因子：
9.7
通讯作者：
Huberman, E
中科院分区：
文献类型：
--
作者：
Floryk, D;Huberman, E
包括麦考酚酸（MPA）在内的肌苷5 '-单磷酸脱氢酶抑制剂是多种不同人类肿瘤细胞类型中的终末分化的有效诱导剂。在这里，我们报告，MPA也诱导雄激素非依赖性前列腺癌细胞系DU 145的分化。MPA诱发复制停滞和积累的DU 145细胞在S期的细胞周期。该抑制剂还诱导了与正常前列腺细胞表型相关的分化标志物CD 55、clusterin、granulophysin、葡萄糖调节蛋白78、血管活性肠多肽和前列腺特异性转氨酶的表达。我们认为，已用于治疗其他疾病的肌苷5 '-单磷酸脱氢酶抑制剂，可作为潜在的分化治疗药物，以控制前列腺癌。(c)2005爱思唯尔爱尔兰有限公司保留所有权利。
Inosine 5'-monophosphate dehydrogenase inhibitors including mycophenolic acid (MPA) are effective inducers of terminal differentiation in a variety of distinct human tumor cell types. Here, we report that MPA also induces such a differentiation in the androgen-independent prostate cancer derived cell line DU145. MPA evoked replication arrest and accumulation of the DU145 cells in the S-phase of the cell cycle. The inhibitor also induced the expression of CD55, clusterin, granulophysin, glucose-regulated protein 78, vasoactive intestinal polypeptide and prostate-specific transglutaminase, which are differentiation markers associated with the phenotype of normal prostate cells. We suggest that inosine 5'-monophosphate dehydrogenase inhibitors, which are already used for the treatment of other diseases, may be used as potential differentiation therapy drugs to control prostate cancer. (c) 2005 Elsevier Ireland Ltd. All rights reserved.