CONNECTIVE-TISSUE DISEASES AND SYMPTOMS ASSOCIATED WITH HASHIMOTOS THYROIDITIS
CONNECTIVE-TISSUE DISEASES AND SYMPTOMS ASSOCIATED WITH HASHIMOTOS THYROIDITIS
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DOI：
10.1056/nejm196302072680601
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发表时间：
1963-01-01
影响因子：
158.5
通讯作者：
FERGUSON, RH
中科院分区：
文献类型：
--
作者：
BECKER, KL;MCCONAHEY, WM;FERGUSON, RH
本文复习了梅奥诊所收治的506例桥本S甲状腺炎的临床资料。其中119例(23.5%)患者同时存在肌肉骨骼疾病或症状。在243例肉芽肿性甲状腺炎患者中，只有3例(1.2%)表现出结缔组织疾病或症状共存。4%的桥本S甲状腺炎患者还伴有类风湿关节炎，与急性肉芽肿性甲状腺炎相比，类风湿关节炎的发病率增加了10倍。此外，7.9%的患者有纤维化综合征，10.7%的患者有其他原因不明的肌肉骨骼症状。异常胸痛综合征发生率为11.9%。在相当大比例的患者中，继发性纤维炎或胸痛不能归因于桥本S甲状腺炎以外的任何过程。其他患者有类风湿性脊柱炎、可能的红斑狼疮、肼丙嗪综合征、干燥S综合征和硬皮病。发生自身免疫反应的能力可能代表着桥本S甲状腺炎和某些胶原蛋白疾病患者的共同特征。
The clinical records of 506 patients with Hashimoto''s thyroiditis seen at the Mayo Clinic are reviewed. Of these, 119 patients (23.5%) had coexistent musculoskeletal diseases or symptoms. Among a group of 243 patients with granulomatous thyroiditis, only 3 (1.2%) manifested coexistent connective-tissue disorders or symptoms. 4% of the patients who had Hashimoto''s thyroiditis also had rheumatoid arthritis, a tenfold increase in the incidence of rheumatoid arthritis as compared with acute granulomatous thyroiditis. In addition 7.9% had a fibrositic syndrome, and 10.7% had other unexplained musculoskeletal symptoms. An unusual chest-pain syndrome was found among 11.9%. In a significant percentage of the patients the secondary fibrositis or chest pain could not be attributed to any process other than Hashimoto''s thyroiditis. Other patients had rheumatoid spondylitis, possible lupus erythematosus, the hydralazine syndrome, SjOgren''s syndrome and scleroderma. The capacity to develop an autoimmune reaction may represent a feature common to patients with Hashimoto''s thyroiditis and certain of the collagen diseases.