High impact of sleeping problems on quality of life in transgender individuals: A cross-sectional multicenter study.
High impact of sleeping problems on quality of life in transgender individuals: A cross-sectional multicenter study.
复制标题
DOI：
10.1371/journal.pone.0171640
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Sievers C
中科院分区：
文献类型：
--
作者：
Auer MK;Liedl A;Fuss J;Nieder T;Briken P;Stalla GK;Hildebrandt T;Biedermann SV;Sievers C
对普通人群的研究表明，生活质量的决定因素通常与性别有关。迄今为止，尚未对跨性别人群的生活质量进行性别依赖性分析。为了确定跨性别患者生活质量的性别特异性和潜在可改变的决定因素在这项横断面多中心研究中，包括不同治疗阶段的 82 名跨性别女性 (TW) 和 72 名跨性别男性 (TM)，我们调查了生活质量的潜在决定因素，重点关注情绪 (BDI、STAI-X)、睡眠质量 (PSQI)、慢性疼痛 (GPQ)、身体形象 (FBeK) 和社会支持 (SSS) 的影响。通过简表 (36) 健康调查 (SF-36) 衡量与健康相关的生活质量。年龄调整后的 SF-36 总分及其分量表在 TM 和 TW 之间没有显着差异。使用多元回归分析方法，我们确定了生活质量的常见但也依赖于性别的决定因素（调整后的 R2 = 0.228；分别为 0.650）。考虑到年龄、BMI 和治疗状态等一般特征，根据 PSQI 的睡眠质量是两性 QoL 的独立且强有力的决定因素（β = -0.451，p = 0.003 TM；β = -0.320；p = 0.0029 TW）。慢性疼痛是 TM 患者生活质量的重要独立预测因子（β = -0.298；p = 0.042），但在 TW 中则不然。相比之下，焦虑（β = -0.451；p < 0.001）、失业（β = -0.206；p = 0.020）和对自己外表的不安全感（FBeK）（β = -0.261；p = 0.01）是台湾人生活质量的独立预测因素。报告严重睡眠障碍（PSQI ≥ 5）的比例较高，TW 为 79.2%，TM 为 81.2%。因此，睡眠质量不佳的人的年龄调整后的生活质量也显着较低。睡眠对两性的生活质量都有很大影响，而疼痛和身体形象等其他因素似乎对跨性别者具有性别特异性。
Studies in the general population suggest that determinants of QoL are often sex-dependent. Sex-dependent analyses of QoL in transgender populations have not been performed so far. To identify sex-specific and potentially modifiable determinants of QoL in transgender patients In this cross-sectional multicentre study including 82 transwomen (TW) and 72 transmen (TM) at different treatment stages, we investigated potential determinants for QoL focusing on the impact of mood (BDI, STAI-X), sleep quality (PSQI), chronic pain (GPQ), body image (FBeK) and social support (SSS). Health-related quality of life measured with the Short Form (36) Health Survey (SF-36). The age-adjusted SF-36 total score and its subscales did not significantly differ between TM and TW. Using a multivariate regression analysis approach, we identified common but also sex-dependent determinants for QoL (Adjusted R2 = 0.228; 0.650 respectively). Accounting for general characteristics such as age, BMI and treatment status, sleep quality according to the PSQI was an independent and strong determinant of QoL in both sexes (β = -0.451, p = 0.003 TM; β = -0.320; p = 0.0029 TW). Chronic pain was a significant independent predictor of QoL in TM (β = -0.298; p = 0.042) but not in TW. In contrast, anxiety (β = -0.451; p< 0.001) being unemployed (β = -0.206; p = 0.020) and insecurity about the own appearance (FBeK) (β = -0.261; p = 0.01) were independent predictors of QoL in TW. The rate of those reporting high sleep disturbances (PSQI ≥5) was high with 79.2% in TW and 81.2% in TM. Accordingly, age-adjusted QoL was also significantly lower in those reporting poor sleep in both sexes. Sleep strongly affected QoL in both genders, while other factors, like pain and body image, seem to be gender specific in transgender individuals.