An Intact Action-Perception Coupling Depends on the Integrity of the Cerebellum
An Intact Action-Perception Coupling Depends on the Integrity of the Cerebellum
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DOI：
10.1523/jneurosci.3276-13.2014
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发表时间：
2014-05-07
影响因子：
5.3
通讯作者：
Timmann, Dagmar
中科院分区：
文献类型：
--
作者：
Christensen, Andrea;Giese, Martin A.;Timmann, Dagmar
人们普遍认为，人类的行动和感知在多个层面上存在功能上的相互作用。此外，最初被认为主要与运动有关的区域，如小脑，也参与了动作观察。然而，到目前为止，很少有研究提供明确的证据表明小脑参与了动作知觉耦合(APC)，特别是在运动和多感觉信息的知觉整合中。我们解决了这个问题，在虚拟现实范式中研究了小脑局灶性病变患者，测量了动作执行对动作知觉的影响，将自我产生的运动呈现为点光源。基于信号检测理论，测量了视觉对点光刺激的敏感度。与健康对照组相比，小脑患者的动作执行对APC的知觉指示缺陷没有明显的影响。应用病变症状图，我们确定了齿状核和两侧小脑外侧区与APC相关的不同区域。右侧腹齿状回、同侧运动代表(小叶V/VI)和对侧小脑后叶(小叶VII)的损害阻碍了运动执行对知觉的益处。我们的结论是，小脑在不同的水平上建立了与时间相关的多感觉表征，与运动控制和支持动作知觉有关。同侧小脑运动表征被认为支持对正在进行的运动的躯体感觉状态的估计，而腹侧齿状回和对侧小脑后脑可能支持小脑-顶环的感觉运动整合。正确的躯体感觉和多感觉状态表征对于完整的APC都是至关重要的。
It is widely accepted that action and perception in humans functionally interact on multiple levels. Moreover, areas originally suggested to be predominantly motor-related, as the cerebellum, are also involved in action observation. However, as yet, few studies provided unequivocal evidence that the cerebellum is involved in the action perception coupling (APC), specifically in the integration of motor and multisensory information for perception. We addressed this question studying patients with focal cerebellar lesions in a virtual-reality paradigm measuring the effect of action execution on action perception presenting self-generated movements as point lights. We measured the visual sensitivity to the point light stimuli based on signal detection theory. Compared with healthy controls cerebellar patients showed no beneficial influence of action execution on perception indicating deficits in APC. Applying lesion symptom mapping, we identified distinct areas in the dentate nucleus and the lateral cerebellum of both hemispheres that are causally involved in APC. Lesions of the right ventral dentate, the ipsilateral motor representations (lobules V/VI), and most interestingly the contralateral posterior cerebellum (lobule VII) impede the benefits of motor execution on perception. We conclude that the cerebellum establishes time-dependent multisensory representations on different levels, relevant for motor control as well as supporting action perception. Ipsilateral cerebellar motor representations are thought to support the somatosensory state estimate of ongoing movements, whereas the ventral dentate and the contralateral posterior cerebellum likely support sensorimotor integration in the cerebellar-parietal loops. Both the correct somatosensory as well as the multisensory state representations are vital for an intact APC.