Distinct preganglionic neurons innervate noradrenaline and adrenaline cells in the cat adrenal medulla
Distinct preganglionic neurons innervate noradrenaline and adrenaline cells in the cat adrenal medulla
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DOI：
10.1016/s0306-4522(96)83019-3
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发表时间：
1996-02-01
期刊：
影响因子：
3.3
通讯作者：
McAllen, RM
中科院分区：
文献类型：
--
作者：
Edwards, SL;Anderson, CR;McAllen, RM
钙视网膜蛋白免疫反应存在于从猫肾上腺逆行标记的一部分节前神经元中。总体而言，三分之一的肾上腺节前神经元显示钙视网膜蛋白免疫反应，并且在更靠尾侧的脊髓节段中其比例增加。钙视网膜蛋白免疫反应阳性的神经末梢在肾上腺内显著，但仅在去甲肾上腺素能嗜铬细胞区域（约占肾上腺髓质面积的三分之一）发现。突触素免疫反应被用于标记有和没有钙视网膜蛋白免疫反应的末梢。缺乏钙视网膜蛋白免疫反应的神经末梢存在于肾上腺素能嗜铬细胞之间，并且也占支配去甲肾上腺素能嗜铬细胞的神经末梢的20%。因此，钙视网膜蛋白免疫反应标记了支配去甲肾上腺素能嗜铬细胞的猫肾上腺节前神经元的一个亚群。
Calretinin immunoreactivity was present in a subset of preganglionic neurons retrogradely labelled from the cat adrenal gland. Overall, one-third of adrenal preganglionic neurons showed calretinin immunoreactivity, and their proportion increased in the more caudal spinal cord segments. Calretinin-immunoreactive nerve terminals were prominent within the adrenal gland, but were found only in areas of noradrenergic chromaffin cells (approximately one-third of the area of the adrenal medulla). Synaptophysin immunoreactivity was used to label terminals with and without calretinin immunoreactivity. Nerve terminals lacking calretinin immunoreactivity were present among the adrenergic chromaffin cells and also comprised 20% of the nerve terminals innervating noradrenergic chromaffin cells.Calretinin immunoreactivity thus labels a subpopulation of cat adrenal preganglionic neurons that innervate the noradrenergic chromaffin cells.