Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate
Synthesis of a key Mycobacterium tuberculosis biosynthetic phosphoinositide intermediate
复制标题
DOI：
10.1016/j.bmcl.2004.04.103
复制
发表时间：
2004-07-16
影响因子：
2.7
通讯作者：
Fraser-Reid, B
中科院分区：
文献类型：
--
作者：
Jayaprakash, KN;Lu, J;Fraser-Reid, B
肌醇受体二醇的区域选择性甘露糖基化容易通过正戊烯基原酸酯的刘易斯酸介导的碘解来实现。该方法提供了一种假三糖，其中添加了磷酸甘油基和其他脂质残基，从而产生分枝杆菌物种的关键生物合成中间体。(C)2004爱思唯尔有限公司保留所有权利。
Regioselective mannosylations of a myoinositol acceptor diol are readily achieved by Lewis acid mediated iodinolysis of n-pentenyl ortho-esters. The procedure affords a psuedotrisaccharide to which the phosphoglyceryl and other lipid residues are added leading to the key biosynthetic intermediate of Mycobacterium species. (C) 2004 Elsevier Ltd. All rights reserved.