The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation rates
The approach to mutation-selection balance in an infinite asexual population, and the evolution of mutation rates
复制标题
DOI：
10.1098/rspb.1999.0936
复制
发表时间：
1999-12-07
影响因子：
4.7
通讯作者：
Johnson, T
中科院分区：
文献类型：
--
作者：
Johnson, T
描述了一种计算无限无性种群中适应度分布动态的方法，该种群受到具有独立效应的无条件有害突变的影响。该方法应用于计算突变亚群频率的问题，由于与有害突变相关，在突变和间接选择之间处于平衡状态。许多突变等位基因是由聚合酶或错配修复基因中的功能丧失突变产生的。之前的计算忽略了这样一个事实，即这会导致适应度较高的个体大量涌入突变子群体。这种通量提高了变异子群的平均适应度，当考虑到这个因素时，变异子的频率可能比最近的理论工作所建议的要大一个数量级以上。
A method is described for calculating the dynamics of the distribution of fitness in an infinite asexual population which is subject to unconditionally deleterious mutations with independent effects. This method is applied to the problem of calculating the frequency of a mutator subpopulation, at equilibrium between mutation and indirect selection due to association with deleterious mutations, Many mutator alleles are produced by loss-of-function mutations in polymerase or mismatch repair genes. Previous calculations have ignored the fact that this creates a flux of higher fitness individuals into the mutator subpopulation. This flux raises the mean fitness of the mutator subpopulation, and when this factor is taken into account, the frequency of the mutator may be more than an order of magnitude greater than recent theoretical work has suggested.