LOCALIZED IN-VIVO H-1 MAGNETIC-RESONANCE SPECTROSCOPY AND IN-VITRO ANALYSES OF HETEROGENEOUS BRAIN-TUMORS
LOCALIZED IN-VIVO H-1 MAGNETIC-RESONANCE SPECTROSCOPY AND IN-VITRO ANALYSES OF HETEROGENEOUS BRAIN-TUMORS
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DOI：
10.1111/jon199553157
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发表时间：
1995-07-01
影响因子：
2.4
通讯作者：
JENDEN, D
中科院分区：
文献类型：
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作者：
CHANG, L;BOOTH, RA;JENDEN, D
脑肿瘤化学模式的磁共振波谱（MRS）研究结果一直不一致。需要实际的生化相关性。在2例异质性颅内肿瘤患者中，体内H-1 MRS和体外生化分析相关。组织学证实了肿瘤的异质性。胆碱在两个肿瘤的细胞部分升高，但在坏死或囊性部分降低。肌酸弥漫性降低，而乳酸在两个肿瘤的所有区域升高。此外，H-1 MRS上胆碱峰的增加似乎是由于水溶性胆碱化合物的增加。这项研究说明了小的局部体素的价值，区分肿瘤的区域化学差异。
Results of magnetic resonance spectroscopic (MRS) studies of the chemical patterns in brain tumors have been inconsistent. Actual biochemical correlations are needed. In 2 patients with heterogeneous intracranial tumors, in vivo H-1 MRS and in vitro biochemical analyses were correlated. Histology confirmed the tumor heterogeneity. Choline was elevated in the cellular portion of both tumors but decreased in the necrotic or cystic portions. Creatine was diffusely decreased while lactate was elevated in all regions of both tumors. Furthermore, the increase in the choline peak on H-1 MRS appeared to be due to increases in water-soluble choline compounds. This study illustrates the value of small localized voxels for differentiating regional chemical differences in tumors.