Genetic analysis of noroviruses associated with fatalities in healthcare facilities
Genetic analysis of noroviruses associated with fatalities in healthcare facilities
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DOI：
10.1007/s00705-006-0739-6
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发表时间：
2006-08-01
影响因子：
2.7
通讯作者：
Shinozaki, K.
中科院分区：
文献类型：
--
作者：
Okada, M.;Tanaka, T.;Shinozaki, K.
2004年至2005年冬季，日本236家老年人医疗机构爆发了诺如病毒疫情。从不同地理位置的设施中分离出与三个致命临床病程相关的三种诺如病毒株，并与同一季节非致命病例的三种病毒株一起进行基因分析。所有六个分离株均被归类为 GII-4 基因型。在致命病例中没有发现像2002年和2004年在欧洲观察到的新变种毒株，这三起疫情被认为是由基因接近的常规诺如病毒GII-4毒株引起的。
Norovirus outbreaks occurred in 236 healthcare facilities for the elderly in Japan during the winter of 2004-2005. Three norovirus strains associated with three fatal clinical courses were isolated from geographically separate facilities and genetically analyzed along with three strains from non-fatal cases in the same season. All six isolates were classified as the GII-4 genotype. No new variant strains like those observed in Europe in 2002 and 2004 were found in fatal cases, and the three outbreaks were deemed to have been caused by genetically close conventional norovirus GII-4 strains.