Effect of l-menthol on laryngeal receptors.
Effect of l-menthol on laryngeal receptors.
复制标题
L-薄荷醇对喉受体的影响。
DOI：
10.1152/jappl.1991.70.2.788
复制
发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Sant'Ambrogio,G
中科院分区：
文献类型：
--
作者：
Sant'Ambrogio,FB;Anderson,JW;Sant'Ambrogio,G
我们研究了l-薄荷醇对喉感受器的作用。在11只麻醉的狗中进行了实验，这些狗通过气管造口术呼吸。我们记录了23个喉冷感受器和19个机械感受器的活动。恒定的空气流量，15-50 ml/s（低）和100-150 ml/s（高），在呼气方向上通过隔离的上气道10 s，降低喉温并激活冷感受器。这种冷诱导的放电在气流撤出后立即停止。对于类似的温度降低，向气流中加入l-薄荷醇诱发比单独的气流更大的冷感受器的峰值激活（低流量164%，高流量111%）;仅对于低流量达到统计学显著性。这种活动持续超过气流停止30-120秒，即使在喉部温度恢复到控制状态时也是如此（仅使用气流的类似试验的低流量237%，高流量307%）。四个喉冷受体也进行了测试，l-薄荷醇添加到一个温暖的，潮湿的气流，不改变喉温度，所有这些都是刺激与持久的放电。九冷受体也测试了d-新薄荷和d-异薄荷;两种异构体刺激受体。测试的19种机械感受器中没有一种受到l-薄荷醇的影响。我们的结论是，l-薄荷醇构成一个特定的刺激喉冷感受器，并可能提供一个有用的工具，为研究其反射效应。
We have studied the effect of l-menthol on laryngeal receptors. Experiments have been conducted in 11 anesthetized dogs that breathed through a tracheostomy. We have recorded the activity of 23 laryngeal cold receptors and 19 mechanoreceptors. Constant flows of air, 15-50 ml/s (low) and 100-150 ml/s (high), passing for 10 s through the isolated upper airway in the expiratory direction, lowered laryngeal temperature and activated the cold receptors. This cold-induced discharge promptly ceased upon withdrawal of the airflow. Addition of l-menthol to the airflow evoked, for a similar decrease in temperature, a greater peak activation of the cold receptors than airflow alone (low flows 164%, high flows 111%); statistical significance was reached only for the lower flow. This activity outlasted the cessation of airflow by 30-120 s, even at a time when laryngeal temperature had returned to control (low flow 237%, high flow 307% of similar trials with airflow alone). Four laryngeal cold receptors were also tested with l-menthol added to a warm, humidified airflow that did not change laryngeal temperature; all of them were stimulated with a long-lasting discharge. Nine cold receptors were also tested with d-neomenthol and d-isomenthol; both isomers stimulated the receptors. None of the 19 mechano-receptors tested was affected by l-menthol. We conclude that l-menthol constitutes a specific stimulant of laryngeal cold receptors and could provide a useful tool for the study of their reflex effects.