Recent progress and applications in glycosaminoglycan and heparin research.
Recent progress and applications in glycosaminoglycan and heparin research.
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DOI：
10.1016/j.cbpa.2009.08.017
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发表时间：
2009-12
影响因子：
7.8
通讯作者：
Linhardt, Robert J.
中科院分区：
文献类型：
--
作者：
Laremore, Tatiana N.;Zhang, Fuming;Dordick, Jonathan S.;Liu, Jian;Linhardt, Robert J.
本次审查的重点是肝素，它是一种极其重要的由动物来源生产的抗凝血药物，去年受到污染，导致了许多不良副作用，有些甚至导致死亡。肝素是一种高酸性多糖，属于糖胺聚糖生物聚合物家族的成员。详细介绍了肝素的结构和活性以及肝素结构分析和生物学评价的最新进展。描述了当前最先进的肝素化学和化学酶合成及其代谢工程的新方法。包括微阵列和数字微流体在内的新技术被提出用于肝素的高通量合成和筛选以及人工高尔基体的制造。
Heparin, the focus of this review, is a critically important anticoagulant drug produced from animal sources, which was contaminated last year leading to a number of adverse side effects, some resulting in death. Heparin is a highly acidic polysaccharide and a member of a family of biopolymers called glycosaminoglycans. The structure and activities of heparin are detailed along with recent advances in heparin structural analysis and biological evaluation. Current state-of-the-art chemical and chemoenzymatic synthesis of heparin and new approaches for its metabolic engineering are described. New technologies, including microarrays and digital microfluidics, are proposed for high-throughput synthesis and screening of heparin and for the fabrication of an artificial Golgi.
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影响因子：
5.7
作者：
Guerrini, Marco;Guglieri, Sara;Torri, Giangiacomo
通讯作者：
Torri, Giangiacomo
影响因子：
46.9
作者：
Guerrini, Marco;Beccati, Daniela;Sasisekharan, Ram
通讯作者：
Sasisekharan, Ram
从肝素污染中学到的经验教训。
影响因子：
11.9
作者：
Liu H;Zhang Z;Linhardt RJ
通讯作者：
Linhardt RJ
DOI：
10.1073/pnas.0806975105
发表时间：
2008-12-02
影响因子：
11.1
作者：
Bethea, Heather N.;Xu, Ding;Pedersen, Lars C.
通讯作者：
Pedersen, Lars C.
影响因子：
15
作者：
Martin, Jeffrey G.;Gupta, Megha;Linhardt, Robert J.
通讯作者：
Linhardt, Robert J.