Inflammation in Response to Glucose Ingestion Is Independent of Excess Abdominal Adiposity in Normal-Weight Women with Polycystic Ovary Syndrome
Inflammation in Response to Glucose Ingestion Is Independent of Excess Abdominal Adiposity in Normal-Weight Women with Polycystic Ovary Syndrome
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DOI：
10.1210/jc.2012-2131
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发表时间：
2012-11-01
影响因子：
5.8
通讯作者：
Minium, Judi
中科院分区：
文献类型：
--
作者：
Gonzalez, Frank;Sia, Chang Ling;Minium, Judi
内容：炎症和过度的腹部肥胖（AA）通常存在于正常体重的妇女与多囊卵巢综合征（PCOS）hide.Objective：我们确定了高血糖对核因子-κ B（NF-κ B B）激活的影响单核细胞（MNC）的正常体重的妇女与多囊卵巢综合征（PCOS）和没有多余的AA。设计：这是一个前瞻性对照研究。设定：研究在一个学术医学中心进行。患者：15名体重正常的育龄PCOS妇女（7名正常AA，8名过量AA）和16名身体成分匹配的对照（8名正常AA，8名过量AA）参加了这项研究。主要结果测量：身体成分通过双能吸收测定法测量。胰岛素敏感性来自口服葡萄糖耐量试验（ISOGTT）。结果：与对照组相比，PCOS组ISOGTT降低，NF κ B B和p65蛋白升高，NF κ B B蛋白降低，NF κ B B和p65蛋白升高，NF κ B B蛋白降低。与AA过多的PCOS患者相比，AA正常的PCOS患者睾酮水平较高，TNF α和CRP水平较低。对于联合组，NF κ B活化的百分比变化与ISOGTT呈负相关，与雄激素呈正相关。TNF α和CRP与腹部脂肪呈正相关。结论：在正常体重的PCOS妇女中，葡萄糖摄入引起的炎症反应与过量AA无关。循环MNC和过量AA是该人群中独立且独特的炎症来源。（临床内分泌代谢杂志97：4071-4079，2012）
Context: Inflammation and excess abdominal adiposity (AA) are often present in normal-weight women with polycystic ovary syndrome (PCOS).Objective: We determined the effects of hyperglycemia on nuclear factor-kappa B (NF kappa B) activation in mononuclear cells (MNC) of normal-weight women with PCOS with and without excess AA.Design: This was a prospective controlled study. Setting: The study was conducted at an academic medical center.Patients: Fifteen normal-weight, reproductive-age women with PCOS (seven normal AA, eight excess AA) and 16 body composition-matched controls (eight normal AA, eight excess AA) participated in the study.Main Outcome Measures: Body composition was measured by dual-energy absorptiometry. Insulin sensitivity was derived from an oral glucose tolerance test (ISOGTT). Activated NF kappa B and the protein content of p65 and inhibitory-kappa B were quantified from MNC, and TNF alpha and C-reactive protein (CRP) were measured in plasma obtained from blood drawn while fasting and 2 h after glucose ingestion.Results: Compared with controls, both PCOS groups exhibited lower ISOGTT, increases in activated NF kappa B and p65 protein, and decreases in inhibitory-kappa B protein. Compared with women with PCOS with excess AA, those with normalAAexhibited higher testosterone levels and lower TNF alpha and CRP levels. For the combined groups, the percent change in NF kappa B activation was negatively correlated with ISOGTT and positively correlated with androgens. TNF alpha and CRP were positively correlated with abdominal fat.Conclusion: In normal-weight women with PCOS, the inflammatory response to glucose ingestion is independent of excess AA. Circulating MNC and excess AA are separate and unique sources of inflammation in this population. (J Clin Endocrinol Metab 97: 4071-4079, 2012)