Genetic and Epidemiologic Characterization of HIV-1 Infection In Liaoning Province, China
Genetic and Epidemiologic Characterization of HIV-1 Infection In Liaoning Province, China
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DOI：
10.1097/qai.0b013e3181c7d5bf
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发表时间：
2010-02-01
影响因子：
3.6
通讯作者：
Shang, Hong
中科院分区：
文献类型：
--
作者：
Han, Xiaoxu;Dai, Di;Shang, Hong
背景资料：尽管中国的许多HIV-1研究都集中在高流行地区的高危注射吸毒者和前献血者，但对相对低流行省份的HIV-1了解甚少。在这里，我们比较的流行病学和遗传特征的HIV-1在辽宁省，一个低流行率的省份，在中国最严重的影响provinces.Materials和方法：2000年和2008年之间，在辽宁省所有主要城市的208例HIV-1阳性者被招募。2.6从血浆病毒RNA中扩增酶gag-pot序列并直接测序。结果：近年来，辽宁省HIV-1感染率虽然保持在较低水平，但新发感染率迅速上升，尤其是男男性行为者和异性恋高危人群（2007年占感染者的54%以上）。此外，系统发育分析确定了辽宁省所有主要亚型/流行的重组形式的HIV-1以前确定的高流行省份。我们的研究还表明HIV-1亚型/循环重组形式与某些危险行为之间存在密切关系。值得注意的是，男性与男性发生性关系和异性恋风险的个人窝藏最不同的株HIV-1从多个高危groups.Conclusions：我们的研究表明，HIV-1继续传播到一般人群通过性接触，辽宁，因此，作为引进和传播的HIV-1在中国东北的关键基地。我们相信本文提出的传播模式将有助于指导公共卫生工作者减少HIV-1在中国的进一步传播。
Background: Although many studies of HIV-1 in China have focused on high-risk injecting drug users and former blood donors in high prevalence regions, little is known about HIV-1 in relatively low prevalence provinces. Here, we compare the epidemiologic and genetic profile of HIV-1 in Liaoning-a low prevalence province-with those identified in China's most severely affected provinces.Materials and Methods: Two hundred eight HIV-1-positive subjects from all major cities in Liaoning province were recruited between 2000 and 2008. 2.6 kilobase gag-pot sequences were amplified from plasma viral RNA and sequenced directly. The HIV-1 sequences obtained, were analyzed using phylogenetic and recombinant approaches.Results: We have shown that in recent years, although HIV-1 prevalence in Liaoning has remained low, the rate of new infection has increased rapidly, particularly among men who have sex with men and heterosexual risk individuals (together comprising >54% of infected individuals in 2007). Furthermore, phylogenetic analysis has identified all major subtypes/circulating recombinant forms of HIV-1 in Liaoning previously identified in high prevalence provinces. Our study also shows close relationships between HIV-1 subtype/circulating recombinant form and certain risk behaviors. Notably, men who have sex with men and heterosexual risk individuals harbor most divergent strains of HIV-1 from multiple high-risk groups.Conclusions: Our Study suggested that HIV-1 continues to spread to the general population through sexual contact; Liaoning, therefore, serves as the critical base for the introduction and spread of HIV-1 in northeast China. We believe the transmission patterns suggested herein will help guide public health workers in reducing further spread of HIV-1 within China.