Autism and Asperger's syndrome.
Autism and Asperger's syndrome.
复制标题
自闭症和阿斯伯格综合症。
DOI：
10.1097/00008480-199708000-00010
复制
发表时间：
1997
影响因子：
3.6
通讯作者：
K. Towbin
中科院分区：
文献类型：
--
作者：
K. Towbin
对包括阿斯伯格综合症在内的自闭症谱系的了解已显着增长。诊断可以更加可靠，并且光谱内元素的表征比以往任何时候都更好。关于自闭症患者所表现出的认知局限性的更清晰的图景正在浮现。功能较低和较高的个体在处理抽象意义、跨情境翻译原则以及关注情境意义方面存在缺陷。 “执行功能”、“心理理论”和功能成像发现之间的联系正变得越来越明显。一致的迹象表明额叶和颞区在这些疾病中起着至关重要的作用。人们已经提出了与特定遗传缺陷的关联，但在得出概括性结论之前，需要能够发现多个基因之间复杂相互作用的方法。
Knowledge about the spectrum of autistic disorders, including Asperger's syndrome, has grown significantly. Diagnoses can be made more reliably and there is better characterization of elements within the spectrum than ever before. A clearer picture of the cognitive limitations displayed by persons with conditions in the autistic spectrum is emerging. Deficits in manipulating abstract meanings, translating principles across contexts, and attending to contextual meanings can be seen in lower and higher functioning individuals. Links between "executive function," "theory of mind," and findings from functional imaging are becoming apparent. There are consistent indications that frontal and temporal regions play a crucial role in these disorders. Associations with specific genetic defects has been suggested, but methods capable of discovering the complex interplay of several genes will be needed before generalized conclusions can be reached.