Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat
Stress and body shape: Stress-induced cortisol secretion is consistently greater among women with central fat
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DOI：
10.1097/00006842-200009000-00005
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发表时间：
2000-09-01
影响因子：
3.3
通讯作者：
Ickovics, JR
中科院分区：
文献类型：
--
作者：
Epel, ES;McEwen, B;Ickovics, JR
目的：过多的中心脂肪会增加患病的风险。在动物实验中，应激诱导的皮质醇分泌已被证明会增加中枢脂肪。本研究的目的是评估具有高腰臀比（WHR）的中心脂肪分布的女性，在一系列身体质量指数中，是否对反复的实验室压力源表现出持续升高的皮质醇反应。方法：59名健康绝经前妇女，腰宽比高30名，腰宽比低29名，连续4天（3个压力组和1个休息组）进行实验室测试。在这些疗程中，皮质醇和心理反应被评估。结果：高WHR的女性认为实验室挑战更具威胁性，表现更差，并且报告了更多的慢性压力。这些女性在第一次压力测试中分泌的皮质醇明显多于WHR较低的女性。此外，高腰宽比的瘦女性缺乏对压力的习惯，在面对熟悉的挑战（第2天和第3天）时，她们比低腰宽比的瘦女性继续分泌更多的皮质醇。结论：中心脂肪分布与更大的心理压力易感性和皮质醇反应性有关。这在身材苗条的女性中尤其如此，她们不习惯重复的压力。目前的横断面研究结果支持了压力诱导的皮质醇分泌可能导致中心脂肪的假设，并证明了心理压力与疾病风险之间的联系。
Objective: Excessive central fat puts one at greater risk of disease. In animal studies, stress-induced cortisol secretion has been shown to increase central fat. The objective of this study was to assess whether women with central fat distribution las indicated by a high waist-to-hip ratio [WHR]), across a range of body mass indexes, display consistently heightened cortisol reactivity to repeated laboratory stressors. Methods: Fifty nine healthy premenopausal women, 30 with a high WHR and 29 with a low WHR, were exposed to consecutive laboratory sessions over 4 days (three stress sessions and one rest session). During these sessions, cortisol and psychological responses were assessed. Results: Women with a high WHR evaluated the laboratory challenges as more threatening, performed more poorly on them, and reported more chronic stress. These women secreted significantly more cortisol during the first stress session than women with a low WHR. Furthermore, lean women with a high WHR lacked habituation to stress in that they continued to secrete significantly more cortisol in response to now familiar challenges (days 2 and 3) than lean women with a low WHR. Conclusions: Central fat distribution is related to greater psychological vulnerability to stress and cortisol reactivity. This may be especially true among lean women, who did not habituate to repeated stress. The current cross-sectional findings support the hypothesis that stress-induced cortisol secretion may contribute to central fat and demonstrate a link between psychological stress and risk for disease.