Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration
Design, synthesis and properties of a degradable polyurethane scaffold for meniscus regeneration
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DOI：
10.1023/b:jmsm.0000021114.39595.1e
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发表时间：
2004-04-01
影响因子：
3.7
通讯作者：
Veth, RPH
中科院分区：
文献类型：
--
作者：
Heijkants, RGJC;Van Calck, RV;Veth, RPH
半月板纵向损伤是膝关节最常见的骨科问题之一。简单技术修复仅局限于半月板的血管区。对于半月板无血管区的修复，一种能辅助机体形成新的半月板细胞组织的支架可能适用。在本研究中，合成了一种以聚（ε - 己内酯）为软段，1,4 - 丁二异氰酸酯和1,4 - 丁二醇为均匀硬段的生物医学嵌段聚氨酯。该材料具有微相分离的形态和优异的力学性能。通过液 - 液相分离和盐析相结合的方法制备了一种多孔支架。所制备的泡沫具有很高的连通性和孔隙率以及所需的压缩模量。在比格犬膝关节内植入6个月后，实现了细胞的完全长入，并且发现支架内形成了类似半月板的组织。此外，其压缩行为似乎与天然半月板组织相当。（C）2004年，克鲁维尔学术出版社。
Longitudinal lesions in menisci are among the most frequent orthopedic problems of the knee. Repair by simple techniques is only limited to the vascular part of the meniscus. For repair of the avascular part of the meniscus a scaffold, which will assist the body in the formation of new meniscus cell tissue, might be applicable. In this study a biomedical segmented polyurethane with poly(epsilon-caprolactone) as soft segment and 1,4-butanediisocyanate and 1,4-butanediol as uniform hard segments has been synthesised. The material has a micro phase separated morphology and excellent mechanical properties. A porous scaffold was prepared via a combination of liquid-liquid phase separation and salt leaching. The foams prepared combined a very high interconnectivity and porosity with the desired compression modulus. After six months of implantation in the knees of beagles full ingrowth with cells was obtained and it was found that meniscus like tissue had been formed in the scaffold. Moreover, compression behaviour appeared to be comparable to native meniscus tissue. (C) 2004 Kluwer Academic Publishers.