Model of the songbird nucleus HVC as a network of central pattern generators
Model of the songbird nucleus HVC as a network of central pattern generators
复制标题
DOI：
10.1152/jn.00438.2016
复制
发表时间：
2016-11-01
影响因子：
2.5
通讯作者：
Abarbanel, Henry D. I.
中科院分区：
文献类型：
--
作者：
Armstrong, Eve;Abarbanel, Henry D. I.
我们提出了一个功能架构的成年鸣禽核HVC的核心元素是一个“功能音节单位”（FSU）。在这个模型中，HVC被组织成FSU，每一个FSU都为发声中的一个音节的产生提供了基础。在每个FSU内，抑制性神经元群体采取两种操作状态之一：1）同时激发，其中所有抑制性神经元同时激发，以及2）抑制性神经元的竞争性激发。这些基本活动模式之间的转换是通过改变抑制性神经元之间的突触强度来实现的。抑制性神经元连接到兴奋性投射神经元，使得在状态1期间投射神经元的活动被抑制，而在状态2期间可以发生投射神经元的顺序放电模式。后一种状态通过从投射到抑制性神经元的反馈来稳定。特定物种的歌曲组成是由不同的FSU在功能上相互连接的方式来区分的。我们的是一个基于生物神经元的计算模型。我们说明，HVC活动的许多观察结果解释的FSU的拟议人口的动态，我们确定目前可测试的实验模型的方面。此外，除了FSU的核心功能，我们建议模式之间的过渡可能是由神经调节的生物物理机制。
We propose a functional architecture of the adult songbird nucleus HVC in which the core element is a "functional syllable unit" (FSU). In this model, HVC is organized into FSUs, each of which provides the basis for the production of one syllable in vocalization. Within each FSU, the inhibitory neuron population takes one of two operational states: 1) simultaneous firing wherein all inhibitory neurons fire simultaneously, and 2) competitive firing of the inhibitory neurons. Switching between these basic modes of activity is accomplished via changes in the synaptic strengths among the inhibitory neurons. The inhibitory neurons connect to excitatory projection neurons such that during state 1 the activity of projection neurons is suppressed, while during state 2 patterns of sequential firing of projection neurons can occur. The latter state is stabilized by feedback from the projection to the inhibitory neurons. Song composition for specific species is distinguished by the manner in which different FSUs are functionally connected to each other. Ours is a computational model built with biophysically based neurons. We illustrate that many observations of HVC activity are explained by the dynamics of the proposed population of FSUs, and we identify aspects of the model that are currently testable experimentally. In addition, and standing apart from the core features of an FSU, we propose that the transition between modes may be governed by the biophysical mechanism of neuromodulation.