Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells
Abilities of β-Estradiol to interact with chemotherapeutic drugs, signal transduction inhibitors and nutraceuticals and alter the proliferation of pancreatic cancer cells
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DOI：
10.1016/j.jbior.2019.100672
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发表时间：
2020-01-01
影响因子：
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通讯作者：
McCubrey, James A.
中科院分区：
文献类型：
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作者：
Akula, Shaw M.;Candido, Saverio;McCubrey, James A.
提高化疗效果和减少化疗副作用是肿瘤研究的重要目标。已经研究了各种方法来增强化疗的有效性。例如，信号转导抑制剂或基于激素的方法已被包括在化疗或放疗中。MIA-PaCa-2和BxPC-3胰腺导管腺癌（PDAC）细胞均表达雌激素受体（ER）。β-雌二醇对PDAC细胞生长的影响尚未被研究，但ER在PDAC细胞中表达。我们研究了β-雌二醇与化疗药物、信号转录抑制剂、天然产物和营养品联合应用对PDAC的影响。在大多数情况下，包括β-雌二醇与化疗药物增加化疗敏感性。这些结果表明，涉及β-雌二醇的一些方法可用于增加化疗药物和其他药物对PDCA生长的有效性。
Improving the effects of chemotherapy and reducing the side effects are important goals in cancer research. Various approaches have been examined to enhance the effectiveness of chemotherapy. For example, signal transduction inhibitors or hormonal based approaches have been included with chemo- or radio-therapy. MIA-PaCa-2 and BxPC-3 pancreatic ductal adenocarcinoma (PDAC) cells both express the estrogen receptor (ER). The effects of beta-estradiol on the growth of PDAC cells has not been examined yet the ER is expressed in PDAC cells. We have examined the effects of combining beta-estradiol with chemotherapeutic drugs, signal transcription inhibitors, natural products and nutraceuticals on PDAC. In most cases, inclusion of beta-estradiol with chemotherapeutic drugs increased chemosensitivity. These results indicate some approaches involving beta-estradiol which may be used to increase the effectiveness of chemotherapeutic and other drugs on the growth of PDCA.