A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore
A Genetic Variant in TGFBR3-CDC7 Is Associated with Visual Field Progression in Primary Open-Angle Glaucoma Patients from Singapore
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DOI：
10.1016/j.ophtha.2015.08.016
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发表时间：
2015-12-01
期刊：
影响因子：
13.7
通讯作者：
Vithana, Eranga
中科院分区：
文献类型：
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作者：
Trikha, Sameer;Saffari, Ehsan;Vithana, Eranga
目的：调查原发性开角型青光眼 (POAG) 的已知基因位点是否与新加坡华人患者的视野 (VF) 进展相关。设计：回顾性研究。参与者：在新加坡医院进行随访的具有 5 次或更多可靠 VF 测量值的患者。方法：使用 Progressor 软件 3.7 版（Medisoft，利兹，英国）识别视野进展。 并由逐点线性回归 (PLR) 标准定义如下：同一半视野中的任意 2 个连续点进行 (
Purpose: To investigate whether known genetic loci for primary open-angle glaucoma (POAG) are associated with visual field (VF) progression in patients from a Singaporean Chinese population.Design: Retrospective study.Participants: Patients with 5 or more reliable VF measurements who were being followed up at a Singapore hospital.Methods: Visual field progression was identified using Progressor software version 3.7 (Medisoft, Leeds, United Kingdom) and defined by pointwise linear regression (PLR) criteria as follows: any 2 contiguous points in the same hemifield progressing (