Cough during infancy and subsequent childhood asthma.
Cough during infancy and subsequent childhood asthma.
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DOI：
10.1111/cea.12573
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发表时间：
2015-09
期刊：
影响因子：
--
通讯作者：
Wright AL
中科院分区：
文献类型：
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作者：
Oren E;Rothers J;Stern DA;Morgan WJ;Halonen M;Wright AL
婴儿期的喘息与随后的哮喘有关，但咳嗽是否同样影响哮喘风险的研究很少。我们试图确定在生命的第一年长时间咳嗽和无感冒咳嗽是否与儿童哮喘有关。婴儿免疫研究是一项非精选出生队列研究，参与者在出生后头9个月内接受了7次关于是否存在喘息和咳嗽的调查。咳嗽超过28天被定义为延长。父母在1岁时被问及孩子是否曾经咳嗽而不感冒。哮喘定义为内科医生诊断哮喘的父母报告，症状或用药年限在2-9年之间。Logistic回归被用来评估与咳嗽特征相关的哮喘的调整优势。24%(97)的儿童在前9个月有长期咳嗽，23%(95)的儿童无感冒咳嗽。与短促咳嗽相比，长时间咳嗽与哮喘风险增加相关(OR 3.57，CI：1.88，6.76)，母亲患有哮喘的孩子的风险尤其高。不感冒咳嗽(OR 3.13，95%CI：1.76，5.57)也与儿童哮喘的风险独立相关。在调整了喘息和1岁时的总IgE后，这两种关系仍然存在。婴儿时期长时间咳嗽和没有感冒的咳嗽与儿童哮喘有关，与婴儿喘息无关。这些发现表明，婴儿期咳嗽的特征是哮喘易感性的早期标志，特别是在患有母体哮喘的儿童中。
Wheezing in infancy has been associated with subsequent asthma, but whether cough similarly influences asthma risk has been little studied. We sought to determine whether prolonged cough and cough without cold in the first year of life are associated with childhood asthma. Participants in the Infant Immune Study, a non-selected birth cohort, were surveyed 7 times in the first 9 months of life regarding presence of wheeze and cough. Cough for more than 28 days was defined as prolonged. Parents were asked at 1 year if the child ever coughed without a cold. Asthma was defined as parental report of physician diagnosis of asthma, with symptoms or medication use between 2–9 years. Logistic regression was used to assess adjusted odds for asthma associated with cough characteristics. 24% (97) of children experienced prolonged cough and 23% (95) cough without cold in the first 9 months, respectively. Prolonged cough was associated with increased risk of asthma relative to brief cough (OR 3.57, CI: 1.88, 6.76), with the risk being particularly high among children of asthmatic mothers. Cough without cold (OR 3.13, 95% CI: 1.76, 5.57) was also independently associated with risk of childhood asthma. Both relations persisted after adjustment for wheeze and total IgE at age 1. Prolonged cough in infancy and cough without cold are associated with childhood asthma, independent of infant wheeze. These findings suggest that characteristics of cough in infancy are early markers of asthma susceptibility, particularly among children with maternal asthma.