REARRANGEMENT OF THE P53 GENE IN HUMAN OSTEOGENIC SARCOMAS
REARRANGEMENT OF THE P53 GENE IN HUMAN OSTEOGENIC SARCOMAS
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DOI：
10.1073/pnas.84.21.7716
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发表时间：
1987-11-01
影响因子：
11.1
通讯作者：
CLINE, MJ
中科院分区：
文献类型：
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作者：
MASUDA, H;MILLER, C;CLINE, MJ
p53是一种53-kDa的核蛋白，其与几种肿瘤模型系统中的恶性转化相关。在134例手术或外周血中获得的人类癌、肉瘤、白血病和淋巴瘤的调查中，我们发现p53基因仅在成骨肉瘤中重排（6例成骨肉瘤中有3例）。其中一名患者的正常组织有一个未重排的基因，表明肿瘤中的遗传异常是后天获得的。其中两个基因重排的肉瘤表达的p53蛋白水平相对于其他肿瘤升高。在人成骨肉瘤细胞系中也发现p53基因重排。
p53 is a 53-kDa nuclear protein that is associated with malignant transformation in several tumor model systems. In a survery of 134 human carcinomas, sarcomas, leukemias, and lymphomas obtained at surgery or from peripheral blood, we found rearrangements of the p53 gene only in osteogenic sarcomas (3 of 6 osteogenic sarcomas examined). Normal tissue from one of these patients had an unrearranged gene, indicating that the genetic abnormality in the tumor was acquired. Two of the sarcomas with rearranged genes expressed levels of p53 protein that were elevated relative to other tumors. Rearranged p53 genes were also found in human osteogenic sarcoma cell lines.