Observation of internal monosaccharide losses in the collisionally activated dissociation mass spectra of anthracycline aminodisaccharides
Observation of internal monosaccharide losses in the collisionally activated dissociation mass spectra of anthracycline aminodisaccharides
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DOI：
10.1016/s1044-0305(98)00036-1
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发表时间：
1998-07-01
影响因子：
3.2
通讯作者：
Traldi, P
中科院分区：
文献类型：
--
作者：
Warrack, BM;Hail, ME;Traldi, P
使用高能和低能碰撞激活解离 (CAD) 研究了蒽环氨基二糖内部单糖残基的损失。在四极杆质谱仪上使用电喷雾电离获得的质谱和低能CAD谱与两个单糖残基位置颠倒的结构一致。在全乙酰化衍生物和氘化类似物的产物离子光谱中观察到的关键碎片离子用于提供重排过程发生的证据。质量分析的离子动能谱数据也与重排一致。 (C) 1998 年美国质谱学会。
The loss of internal monosaccharide residues from anthracycline aminodisaccharides has been studied using high and low energy collisionally activated dissociations (CAD). The mass spectra and low energy CAD spectra obtained using electrospray ionization on a quadrupole mass spectrometer were consistent with a structure in which positions of the two monosaccharide residues were reversed. Key fragment ions observed in the product ion spectra of the peracetylated derivative and the deuterated analog were used to provide evidence that a rearrangement process had occurred. Mass-analyzed ion kinetic energy spectrometry data were also consistent with a rearrangement. (C) 1998 American Society for Mass Spectrometry.