Dietary chloride and bicarbonate as determinants of desoxycorticosterone hypertension.
Dietary chloride and bicarbonate as determinants of desoxycorticosterone hypertension.
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发表时间：
1984-12
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通讯作者：
T. Kurtz;R. Morris
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作者：
T. Kurtz;R. Morris
在单侧肾切除大鼠给予脱氧皮质酮（DOC）和固定量的膳食钠，我们试图确定是否消耗的钠盐的阴离子成分可能是高血压的发生和维持的致病决定因素。两周后，给予DOC和NaCl的大鼠的平均动脉压（MAP）显著高于给予DOC和NaHCO3或NaCl而不给予DOC的大鼠。用接近等摩尔量的NaHCO3代替饮食中的NaCl纠正了高血压。用接近等摩尔量的NaCl代替饮食中的NaHCO3诱导高血压。这些发现不能归因于热量摄入、体重增加或钠或钾的外部平衡的变化。这些发现表明，在给予DOC和固定量的膳食钠的大鼠中，所消耗的钠盐的阴离子组分可以决定高血压的发生、进展和逆转。
In uninephrectomized rats given desoxycorticosterone (DOC) and a fixed amount of dietary sodium, we sought to determine if the anionic component of the sodium salt consumed could be a pathogenetic determinant of the occurrence and maintenance of hypertension. After two weeks, mean arterial pressure (MAP) in rats given DOC and NaCl was significantly greater than in rats given DOC and NaHCO3, or NaCl without DOC. Replacing dietary NaCl with a near equimolar amount of NaHCO3 corrected the hypertension. Replacing dietary NaHCO3 with a near equimolar amount of NaCl induced hypertension. These findings could not be attributed to changes in caloric intake, weight gain, or external balances of sodium or potassium. These findings demonstrate that, in rats given DOC and a fixed amount of dietary sodium, the anionic component of the sodium salt consumed can determine the occurrence, progression, and reversal of hypertension.