The role of adiponectin multimers in anorexia nervosa
The role of adiponectin multimers in anorexia nervosa
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DOI：
10.1016/j.nut.2012.07.011
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发表时间：
2013-01-01
期刊：
影响因子：
4.4
通讯作者：
Inui, Akio
中科院分区：
文献类型：
--
作者：
Amitani, Haruka;Asakawa, Akihiro;Inui, Akio
目的：神经性厌食症(ANN)因其发病机制不明，一直是难治性疾病。脂联素在AN中的作用尚不清楚。此外，很少有报道描述脂联素亚型与AN在生理和心理状态下的关系。因此，我们检测了AN患者的血浆脂联素及其异构体水平，以了解它们在AN中的作用。方法：18名女性参与了这项研究：9名AN患者和9名年龄匹配的健康对照组。我们检测了所有受试者的血浆脂联素及其异构体水平，并对AN患者进行了三种类型的心理测试：饮食紊乱问卷-2、Maudsley强迫症状问卷和Beck抑郁问卷-2。结果：与对照组相比，AN组大分子质量(HMW)占总脂联素(%HMW)的百分比显著降低，而低分子质量(LMW)占总脂联素(%LMW)的百分比显著升高。在整个研究人群中，%HMW和%LMW与体重指数呈正相关和负相关。%HMW与心理症状呈正相关，如社交不安全感或清洁，用饮食障碍问卷-2或Maudsley强迫-强迫问卷进行评估。结论：我们的研究表明，在AN患者中，除总脂联素外，还应评估所有脂联素亚型。本组患者的%HMW降低和%LMW升高与体重指数和精神病理的某些成分相关，可能表明脂联素亚型在极端营养不良期间维持能量稳态和情绪的复杂作用。(C)2013 Elsevier Inc.保留所有权利。
Objective: Anorexia nervosa (AN) continues to be a refractory disease because of its unknown pathogenesis. The role of adiponectin in AN has not been clarified. Moreover, few reports have described the relations between adiponectin isoforms and AN in the physical and psychological states. Therefore, we measured plasma adiponectin and its isoforms levels in patients with AN to examine their roles in AN.Methods: Eighteen women participated in this study: nine patients with AN and nine age-matched healthy controls. We examined plasma adiponectin and its isoforms levels in all subjects and administered three types of psychological test to patients with AN: the Eating Disorders Inventory-2, the Maudsley Obsessional-Compulsive Inventory, and the Beck Depression Inventory-2.Results: We found that the percentage of high-molecular-weight (HMW) to total adiponectin (%HMW) was significantly low and the percentage of low-molecular-weight (LMW) to total adiponectin (%LMW) was significantly high in the AN group compared with the control group. The %HMW positively and the %LMW negatively correlated with body mass index in the entire study population. The %HMW was also positively correlated with psychological symptoms such as social insecurity or cleaning evaluated with the Eating Disorders Inventory-2 or the Maudsley Obsessional-Compulsive Inventory.Conclusions: Our study indicates that all adiponectin isoforms should be evaluated in patients with AN in addition to total adiponectin. The decreased %HMW and the increased %LMW that were correlated with the body mass index and some components of psychopathology in our patients may indicate a complex role of adiponectin isoforms in maintaining energy homeostasis and emotion during extreme malnourishment. (C) 2013 Elsevier Inc. All rights reserved.