Validation of an electronic image reader training programme for interpretation of [18F]flutemetamol β-amyloid PET brain images.
Validation of an electronic image reader training programme for interpretation of [18F]flutemetamol β-amyloid PET brain images.
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DOI：
10.1097/mnm.0000000000000633
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发表时间：
2017-03
影响因子：
1.5
通讯作者：
Brooks DJ
中科院分区：
文献类型：
--
作者：
Buckley CJ;Sherwin PF;Smith AP;Wolber J;Weick SM;Brooks DJ
开发了电子培训程序 (ETP)，用于在 PET 淀粉样蛋白显像剂 [18F]氟替他莫注射液 (VIZAMYL) 的常规临床使用过程中解释图像。进行这项研究是为了验证 ETP。五名核医学技术人员 (NMT) 和五名以前在淀粉样蛋白图像解读方面缺乏经验的读者需要使用 ETP 进行自我训练并通过测试才能参与。然后将总共 305 张 [18F]氟替他莫 PET 图像作为验证集进行测试，并由五个 NMT 之一进行预评估和重新定向（如果需要）。接下来，一组新的不了解临床信息的读者独立评估了所有 305 张图像。在之前的研究中，图像是从代表全方位认知能力的患者身上获取的。如果可用，则使用由组织病理学或临床病史确定的真实标准来从该验证集得出图像解释的敏感性和特异性。随机选择的图像 (n=29) 重复读取，以测量读取器内的再现性。首先读取没有解剖图像的图像，然后读取解剖图像（如果有）。所有 NMT 和所有读者在资格测试中得分均为 100%。在没有解剖图像支持的情况下对 135 例病例进行解读，结果敏感性为 84% 至 94%（大多数为 94%，中位数为 92%），特异性为 77% 至 96%（大多数为 92%，中位数为 81%）。读者间的一致性非常高，大多数 κ 分数都超过 0.8。阅读器内的再现性范围为 93% 至 100%。自引导 ETP 有效地训练了新的淀粉样蛋白 PET 图像读取器，以准确且可重复地解读 [18F]氟替他莫 PET 图像。
An electronic training programme (ETP) was developed for interpretation of images during routine clinical use of the PET amyloid imaging agent [18F]flutemetamol injection (VIZAMYL). This study was carried out to validate the ETP. Five nuclear medicine technologists (NMTs) and five readers previously inexperienced in amyloid image interpretation were required to self-train using the ETP and pass a test to participate. A total of 305 [18F]flutemetamol PET images were then tested as the validation set, following preassessment and reorientation (where required) by one of five NMTs. Next, a new set of readers blinded to clinical information independently assessed all 305 images. Images had been acquired in previous studies from patients representing the full spectrum of cognitive capacity. When available, a standard of truth determined by histopathology or clinical history was used to derive sensitivity and specificity for image interpretation from this validation set. Randomly selected images (n=29) were read in duplicate to measure intrareader reproducibility. Images were read first without, and subsequently with anatomic images, if available. All NMTs and all readers scored 100% on the qualifying test. The interpretation of 135 cases without anatomic image support resulted in sensitivity ranging from 84% to 94% (majority 94%, median 92%) and specificity ranging from 77% to 96% (majority 92%, median 81%). Inter-reader agreement was very high, with most κ scores more than 0.8. Intrareader reproducibility ranged from 93 to 100%. The self-guided ETP effectively trained new amyloid PET image readers to accurately and reproducibly interpret [18F]flutemetamol PET images.