Amygdalofrontal Functional Disconnectivity and Aggression in Schizophrenia
Amygdalofrontal Functional Disconnectivity and Aggression in Schizophrenia
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DOI：
10.1093/schbul/sbp012
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发表时间：
2010-09-01
影响因子：
6.6
通讯作者：
Milham, Michael P.
中科院分区：
文献类型：
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作者：
Hoptman, Matthew J.;D'Angelo, Debra;Milham, Michael P.
很大一部分精神分裂症患者表现出背侧前额叶区域的异常，包括背外侧前额叶和背侧前扣带皮层。然而，目前尚不清楚腹侧前额叶和边缘区域的异常程度如何，尽管它们与社会认知功能障碍和攻击性有关，而这些是精神分裂症患者的问题领域。此前，我们发现右下额叶区域白质完整性降低与更高水平的攻击性相关。在这里，我们使用静息态功能磁共振成像来检查杏仁核/腹侧前额叶皮层（vPFC）功能连接（FC）及其与精神分裂症攻击行为的关系。 21 名健康对照者和 25 名精神分裂症或分裂情感障碍患者参与了研究。使用巴斯佩里攻击行为问卷来测量攻击行为。根据之前发表的工作，将感兴趣的区域放置在杏仁核中。进行了体素 FC 分析，其中将双侧杏仁核种子的体素平均时间序列作为预测变量输入到多元回归模型中，其中运动参数和全局、脑脊液和白质信号作为协变量。患者杏仁核和 vPFC 区域之间的 FC 显着降低。此外，在患者中，这种联系的强度与攻击性呈显着的负相关，因此较低的 FC 与较高水平的自评攻击性相关。其他两项指标（攻击性生活史和逮捕总数）也获得了类似的结果。这些结果表明杏仁核/vPFC FC 在精神分裂症中受到损害，并且这种损害与攻击性有关。
A significant proportion of patients with schizophrenia demonstrate abnormalities in dorsal prefrontal regions including the dorsolateral prefrontal and dorsal anterior cingulate cortices. However, it is less clear to what extent abnormalities are exhibited in ventral prefrontal and limbic regions, despite their involvement in social cognitive dysfunction and aggression, which represent problem domains for patients with schizophrenia. Previously, we found that reduced white matter integrity in right inferior frontal regions was associated with higher levels of aggression. Here, we used resting-state functional magnetic resonance imaging to examine amygdala/ventral prefrontal cortex (vPFC) functional connectivity (FC) and its relation to aggression in schizophrenia. Twenty-one healthy controls and 25 patients with schizophrenia or schizoaffective disorder participated. Aggression was measured using the Buss Perry Aggression Questionnaire. Regions of interest were placed in the amygdala based on previously published work. A voxelwise FC analysis was performed in which the mean time series across voxels for this bilateral amygdala seed was entered as a predictor in a multiple regression model with motion parameters and global, cerebrospinal fluid, and white matter signals as covariates. Patients showed significant reductions in FC between amygdala and vPFC regions. Moreover, in patients, the strength of this connection showed a significant inverse relationship with aggression, such that lower FC was associated with higher levels of self-rated aggression. Similar results were obtained for 2 other measures-Life History of Aggression and total arrests. These results suggest that amygdala/vPFC FC is compromised in schizophrenia and that this compromise is associated with aggression.