Cardiotonic action of plumbagin on guinea-pig papillary muscle.
Cardiotonic action of plumbagin on guinea-pig papillary muscle.
复制标题
白花丹素对豚鼠乳头肌的强心作用。
作者：
M. Itoigawa;K. Takeya;H. Furukawa
白花丹素是白丹科植物的一种活性成分，可在豚鼠乳头肌中产生三相正性肌力反应（第一正相、第二负相和第三正相）。白花丹素在第一个正期的正性肌力效力为pD2 6.40，白花丹素5-羟基的甲基化降低了效力。白花丹素的三相正性模式不受利血平或普萘洛尔治疗的影响。在缺氧条件下或在线粒体氧化磷酸化抑制剂（例如 2,4-二硝基苯酚和二香豆素）存在下，白花丹素不会产生正性肌力作用。
Plumbagin, an active principle from Plumbaginaceous plants, produced a triphasic inotropic response (first positive, second negative, and third positive phases) in guinea-pig papillary muscle. The inotropic potency of plumbagin at the first positive phase was pD2 6.40, and the methylation of 5-hydroxy group of plumbagin reduced the potency. The triphasic pattern of inotropism of plumbagin was unaffected by reserpine or propranolol treatments. Plumbagin did not produce the positive inotropic effects under anoxic conditions or in the presence of mitochondrial oxidative phosphorylation inhibitors such as 2,4-dinitrophenol and dicumarol.