Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
Strategies for the use of insulin-sensitizing drugs to treat infertility in women with polycystic ovary syndrome
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DOI：
10.1016/s0015-0282(01)02963-6
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发表时间：
2002-02-01
影响因子：
6.7
通讯作者：
Jakubowicz, DJ
中科院分区：
文献类型：
--
作者：
Nestler, JE;Stovall, D;Jakubowicz, DJ
目的：胰岛素抵抗及其代偿性高胰岛素血症在多囊卵巢综合征（PCOS）不孕中起重要作用。许多研究表明，胰岛素增敏药物可用于增强自发排卵和诱导排卵的综合征。本综述的目的是总结胰岛素增敏药物用于增加PCOS妇女排卵率或提高生育能力的研究，并将这些信息转化为生殖内分泌学家使用这些药物的实用指南。设计：回顾和评论的研究，其中胰岛素-采用增敏药物提高多囊卵巢综合征患者的排卵率或改善不孕症。主要观察指标：排卵率和妊娠率。结果：研究表明，胰岛素增敏药物可增加自发排卵，增强克罗米芬的促排卵作用，提高临床妊娠率。结论：为胰岛素增敏药物治疗多囊卵巢综合征无排卵和不孕提供了一种算法。（Fertil Steril（R）2002;77：209-15. (C)2002年，美国生殖医学会（American Society for Reproductive Medicine）。
Objective: Insulin resistance and its compensatory hyperinsulinemia play a key pathogenic role in the infertility of the polycystic ovary syndrome. Numerous studies indicate that insulin-sensitizing drugs can be used to enhance spontaneous ovulation and the induction of ovulation in the syndrome. The aim of this review is to summarize the studies in which insulin-sensitizing drugs were used to increase ovulation rate or improve fertility in women with the PCOS and to translate the information into practical guidelines for the use of these drugs by reproductive endocrinologists.Design: Review and critique of studies in which an insulin-sensitizing drug was used to increase ovulation rate or improve infertility in women with the polycystic ovary syndrome.Main Outcome Measure(s): Ovulation rate and pregnancy rate.Result(s): Studies have demonstrated that insulin-sensitizing drugs can increase spontaneous ovulation, enhance the induction of ovulation with clomiphene citrate, and increase clinical pregnancy rates.Conclusion(s): An algorithmic approach is provided for the use of insulin-sensitizing drugs to treat the anovulation and infertility of women with the polycystic ovary syndrome. (Fertil Steril(R) 2002;77:209-15. (C) 2002 by American Society for Reproductive Medicine.).