3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles
3D printing of five-in-one dose combination polypill with defined immediate and sustained release profiles
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DOI：
10.1016/j.jconrel.2015.09.028
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发表时间：
2015-11-10
影响因子：
10.8
通讯作者：
Roberts, Clive J.
中科院分区：
文献类型：
--
作者：
Khaled, Shaban A.;Burley, Jonathan C.;Roberts, Clive J.
我们已经使用三维（3D）挤压印刷来制造一种多活性固体剂型或所谓的复方药片。它包含五种区隔药物，具有两个独立控制和定义良好的释放概况。这种复合药片表明，复杂的药物治疗方案可以结合在一个单一的个性化药片。这可能会提高那些目前服用许多单独药片的患者的依从性，也可以根据个人需要随时调整特定的药物组合/药物释放。这种多药片代表了一种心血管治疗方案，包括一个含有阿司匹林和氢氯噻嗪的立即释放室和三个含有普伐他汀、阿替洛尔和雷米普利的缓释室。采用x射线粉末衍射（XRPD）和衰减全反射傅里叶变换红外光谱（ATR-FTIR）评价药物与辅料的相互作用。采用USP溶出度法评价印制的多片剂的释放度。我们发现，根据所使用的活性/赋形剂比例，该复方制剂显示出预期的立即和持续释放。(c) 2015 Elsevier B.V.版权所有
We have used three dimensional (3D) extrusion printing to manufacture a multi-active solid dosage form or so called polypill. This contains five compartmentalised drugs with two independently controlled and well-defined release profiles. This polypill demonstrates that complex medication regimes can be combined in a single personalised tablet. This could potentially improve adherence for those patients currently taking many separate tablets and also allow ready tailoring of a particular drug combination/drug release for the needs of an individual. The polypill here represents a cardiovascular treatment regime with the incorporation of an immediate release compartment with aspirin and hydrochlorothiazide and three sustained release compartments containing pravastatin, atenolol, and ramipril. X-ray powder diffraction (XRPD) and Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy (ATR-FTIR) were used to assess drug-excipient interaction. The printed polypills were evaluated for drug release using USP dissolution testing. We found that the polypill showed the intended immediate and sustained release profiles based upon the active/excipient ratio used. (c) 2015 Elsevier B.V. All rights reserved.