Stereoselective Synthesis of Multiple Stereocenters by Using a Double Aldol Reaction
Stereoselective Synthesis of Multiple Stereocenters by Using a Double Aldol Reaction
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DOI：
10.1002/anie.201209848
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发表时间：
2013-01-01
影响因子：
16.6
通讯作者：
Nakajima, Makoto
中科院分区：
文献类型：
--
作者：
Shimoda, Yasushi;Kubo, Tatsunori;Nakajima, Makoto
三合一：使用手性(S)-联胺作为路易斯碱催化剂，烷基甲基酮和两个醛的标题反应允许在一次操作中获得具有多个手性中心的1，5-二羟基-3-戊酮衍生物，并且具有高的非对映和对映选择性(见方案)。
Triple play: The title reaction of an alkyl methyl ketone and two aldehydes using chiral (S)‐binapo as a Lewis base catalyst allows access to 1, 5‐dihydroxy‐3‐pentanone derivatives with multiple chiral centers in good yields with high diastereo‐and enantioselectivities in a single operation (see scheme).