Perspective on taxonomic classification of uncultivated viruses
Perspective on taxonomic classification of uncultivated viruses
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DOI：
10.1016/j.coviro.2021.10.011
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发表时间：
2021-11-12
影响因子：
5.9
通讯作者：
Sullivan, Matthew B.
中科院分区：
文献类型：
--
作者：
Dutilh, Bas E.;Varsani, Arvind;Sullivan, Matthew B.
从历史上看，病毒分类学一直局限于描述在实验室中容易培养或在自然生物群中出现的病毒。元基因组分析、单颗粒测序和数据库挖掘工作已经产生了关于数量惊人的以前未知的病毒的新的序列数据。由于元基因组相对没有偏见，这些数据为病毒圈的浩瀚提供了前所未有的洞察，但为了正确评估这种多样性的程度，对病毒进行分类是至关重要的。包括未培养的病毒已经改善了这一过程以及对分类群、病毒及其进化关系的理解。需要不断开发和测试计算工具，以保持动态的病毒分类，以适应新的发现。
Historically, virus taxonomy has been limited to describing viruses that were readily cultivated in the laboratory or emerging in natural biomes. Metagenomic analyses, single particle sequencing, and database mining efforts have yielded new sequence data on an astounding number of previously unknown viruses. As metagenomes are relatively free of biases, these data provide an unprecedented insight into the vastness of the virosphere, but to properly value the extent of this diversity it is critical that the viruses are taxonomically classified. Inclusion of uncultivated viruses has already improved the process as well as the understanding of the taxa, viruses, and their evolutionary relationships. The continuous development and testing of computational tools will be required to maintain a dynamic virus taxonomy that can accommodate the new discoveries.