CLINICAL-TRIALS OF ARTEMISININ AND ITS DERIVATIVES IN THE TREATMENT OF MALARIA IN CHINA
CLINICAL-TRIALS OF ARTEMISININ AND ITS DERIVATIVES IN THE TREATMENT OF MALARIA IN CHINA
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DOI：
10.1016/0035-9203(94)90460-x
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发表时间：
1994-06-01
影响因子：
2.2
通讯作者：
WANG, XH
中科院分区：
文献类型：
--
作者：
LI, GQ;GUO, XB;WANG, XH
自1979年以来，我国已合成和研究了几种青蒿素衍生物。青蒿素栓剂、青蒿琥酯（口服或注射）、肌内注射蒿甲醚和双氢青蒿素片剂都证明迅速有效。总共有2352例患者（2150例恶性疟原虫和202例间日疟原虫）被纳入我们中心的临床试验。所有制剂均耐受良好。这些药物现已取代氯喹和奎宁在中国治疗疟疾。
Since 1979 several derivatives of artemisinin have been synthesized and studied in China. Artemisinin suppositories, artesunate (oral or parenteral), intramuscular artemether and dihydroartemisinin tablets have all proved rapidly effective. In all, 2352 patients (2150 with Plasmodium falciparum and 202 with P. vivax) have been included in clinical trials from our centre. All preparations have been well tolerated. These drugs have now replaced chloroquine and quinine for the treatment of malaria in China.