Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women
Aerobic exercise training increases plasma Klotho levels and reduces arterial stiffness in postmenopausal women
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DOI：
10.1152/ajpheart.00429.2013
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发表时间：
2014-02-01
影响因子：
4.8
通讯作者：
Maeda, Seiji
中科院分区：
文献类型：
--
作者：
Matsubara, Tomoko;Miyaki, Asako;Maeda, Seiji
Klotho基因是衰老现象的抑制因子，随着年龄的增长，Klotho蛋白的分泌和循环减少。尽管习惯性运动具有抗衰老作用（例如，降低动脉硬化），但Klotho与习惯性运动之间的关系尚不清楚。在目前的研究中，我们调查了习惯性运动对Klotho的影响，特别关注动脉僵硬。首先，我们通过横断面研究检测了69名健康绝经后妇女（50-76岁）血浆Klotho浓度与动脉僵硬度（颈动脉顺应性和β -僵硬指数）或有氧运动能力（通气阈值摄氧量）之间的相关性。其次，我们测试了有氧运动训练对血浆Klotho浓度和动脉硬度的影响。19名50-76岁的健康绝经后妇女被分为两组：对照组和运动组。运动组完成12周的适度有氧运动训练。横断面研究中，血浆Klotho浓度与颈动脉顺应性和VT呈正相关，与β -僵硬指数负相关。在介入研究中，有氧运动训练增加了血浆Klotho浓度和颈动脉顺应性，降低了β -僵硬指数。此外，血浆Klotho浓度的变化与动脉僵硬度存在相关性。这些结果表明，分泌的Klotho可能在运动诱导的动脉僵硬调节中起作用。
The Klotho gene is a suppressor of the aging phenomena, and the secretion as well as the circulation of Klotho proteins decrease with aging. Although habitual exercise has antiaging effects (e. g., a decrease in arterial stiffness), the relationship between Klotho and habitual exercise remains unclear. In the present study, we investigated the effect of habitual exercise on Klotho, with a particular focus on arterial stiffness. First, we examined the correlation between plasma Klotho concentration and arterial stiffness (carotid artery compliance and beta-stiffness index) or aerobic exercise capacity [oxygen uptake at ventilatory threshold (VT)] in 69 healthy, postmenopausal women (50-76 years old) by conducting a cross-sectional study. Second, we tested the effects of aerobic exercise training on plasma Klotho concentrations and arterial stiffness. A total of 19 healthy, postmenopausal women (50-76 years old) were divided into two groups: control group and exercise group. The exercise group completed 12 wk of moderate aerobic exercise training. In the cross-sectional study, plasma Klotho concentrations positively correlated with carotid artery compliance and VT and negatively correlated with the beta-stiffness index. In the interventional study, aerobic exercise training increased plasma Klotho concentrations and carotid artery compliance and decreased the beta-stiffness index. Moreover, the changes in plasma Klotho concentration and arterial stiffness were found to be correlated. These results suggest a possible role for secreted Klotho in the exercise-induced modulation of arterial stiffness.