A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”
A suggestion to introduce the diagnosis of “diffuse midline glioma of the pons, H3 K27 wildtype (WHO grade IV)”
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建议介绍“脑桥弥漫性中线胶质瘤，H3 K27野生型（WHO IV级）”的诊断
DOI：
10.1007/s00401-018-1863-6
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发表时间：
2018
影响因子：
12.7
通讯作者：
C. Kramm
中科院分区：
文献类型：
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作者：
A. V. von Bueren;M. Karremann;G. Gielen;M. Benesch;M. Fouladi;D. V. van Vuurden;S. V. van Zanten;L. Hoffman;C. Kramm
我们非常感兴趣地阅读了Louis等人发表的关于澄清弥漫性中线胶质瘤H3 k27m突变体标准的文章，并希望对以下观点进行讨论。近20年来，儿科神经肿瘤学家普遍认为，神经影像学定义的弥漫性内在脑桥胶质瘤（DIPG）与组织学分级无关，预后很差（活检时）。因此，活检通常被忽略，直到最近发现了个体化治疗的潜在药物靶点，这导致了对这种方法的重新评估[10]。然而，活检只在少数DIPG患者中进行（诚然越来越多！）；在大多数病例中，诊断仍然是通过典型的MRI特征[t1 -低（或等）强度和t2 -高强度肿瘤累及至少50%的脑桥]以及非常短的临床病史（通常< 6个月），以及至少一种典型的脑干症状（颅神经缺损，共济失调和/或长束体征）来建立的。
We have read with great interest the publication regarding clarification of criteria for diffuse midline glioma, H3 K27M-mutant by Louis et al.[5] and would like to contribute to the discussion the following point. It has been common sense now for nearly 20 years among pediatric neurooncologists that neuroradiologically defined diffuse intrinsic pontine gliomas (DIPG) display a very poor prognosis independent of histological grade (when biopsied). Thus, biopsies had been usually omitted until recent identification of potential drug targets for individualized therapy has led to reevaluation of this approach [8]. Nevertheless, biopsies are only performed in the (admittedly growing!) minority of DIPG patients; in the majority of cases, diagnosis is still established by typical MRI features [T1-hypo (or iso) intense and T2-hyperintense tumor involving at least 50% of the pons] together with a very short clinical history (usually< 6 months), and at least one typical brainstem symptom (cranial nerve deficits, ataxia and/or long tract signs)[1].
D/L-氨基酸谱创造新美容和功能食品的可能性
DOI：
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发表时间：
2014
期刊：
影响因子：
--
作者：
Naoki Tsunekawa;Nobuaki Higashi;Tatsuro Irimura.;Kaori Denda-Nagai and Tatsuro Irimura;入村達郎;浜瀬健司;浜瀬健司
通讯作者：
浜瀬健司
影响因子：
45.3
作者：
Lassaletta, Alvaro;Scheinemann, Katrin;Bouffet, Eric
通讯作者：
Bouffet, Eric